肿瘤预防与治疗2019，Vol.32Issue(4)：311-318,8.DOI:10. 3969/j. issn. 1674-0904. 2019. 04. 004
NSCLC根治术后 pN2 期患者不同放化疗模式的疗效分析
Effect of Different Radiotherapy and Chemotherapy Modes on Patients with pN2 Stage NSCLC after Radical Operation
摘要
Abstract
Objective: To compare the value of sequential radiochemotherapy (SCRT) and concurrent chemoradiotherapy (CCRT) in adjuvant treatment of pN2 patients with non-small cell lung cancer (NSCLC) after radical resection. Methods:Ninety-two pN2 NSCLC patients after surgery in Sichuan cancer hospital from January 2012 to December 2017 were selected and divided into two groups, SCRT group (n=54) and CCRT group (n=38), according to different chemoradiotherapies. Side effects, local recurrence free survival (LRFS), distant metastasis free survival (DmFS), disease-free survival (DFS), overall survival ( OS) and 1- , 2-and 3-year survival rates were compared between the two groups. Results: There was no significant difference in general information, pathological type, pathological T stage and lymph node status between the two groups. The incidence of leukopenia in CCRT group was higher than that in SCRT group (P<0. 05). There was no significant difference between the two groups in the incidence of side effects such as radiation esophagitis and radiation pneumonia (P>0. 05). Median DmFS and DFS in SCRT group were better than those in CCRT group. Median LRFS in both groups and median OS in the CCRT group were not retrieved. But the differences were not significantly different between the two groups in median DmFS, DFS, LRFS and OS (P>0. 05). Conclusion: For pN2 stage NSCLC patients underwent radical resection, SCRT and CCRT are effective treatment methods, and the safety of SCRT is better. DmFS and DFS from SCRT are better than those from CCRT. The value of SCRT and CCRT needs to be further explored.关键词
N2/非小细胞肺癌/序贯/同步/放化疗Key words
N2/Non small cell lung cancer/Sequential/Concurrent/Chemoradiotherapy分类
医药卫生引用本文复制引用
Li Xiujuan,Luo Xingbo,Zhang Jing,Xie Xiaohui,Peng Xiaoqin,Yao Wenxiu..NSCLC根治术后 pN2 期患者不同放化疗模式的疗效分析[J].肿瘤预防与治疗,2019,32(4):311-318,8.基金项目
吴阶平医学基金会临床科研专项资助基金课题(编号: 320. 6750. 12670) This study was supported by Clinical Research Project of Wu Jieping medical Foundation (NO. 320. 6750. 12670) . （编号: 320. 6750. 12670）
