肿瘤预防与治疗2019，Vol.32Issue(4)：324-330,7.DOI:10. 3969/j. issn. 1674-0904. 2019. 04. 006
乳腺癌组织中Livin和Smac的表达及其临床意义
Expressions of Livin and Smac Proteins in Breast Cancer and Their Clini-cal Significance
摘要
Abstract
Objective: To explore the expression and clinic-pathological characteristics of Livin and Smac in breast carci-noma tissue. Methods: S-P immunohistochemical staining was adopted to examine the expression of Livin and Smac; breast cancer samples (n=43) were assembled from West China Hospital, Sichuan University. Results: The positive expression of Livin in breast cancer tissue was 79. 1% , and it was 48. 8% in paracarcinoma tissue. The difference between the two groups was statistically significant (P<0. 05). meanwhile, the positive expression of Smac in breast cancer tissue was 74. 4% , and it was 93. 0% in paracarcinoma tissue. The difference between the two groups was statistically significant (P<0. 05). Livin protein expression in breast cancer was closely related to clinical stage and lymph node metastasis ( P<0. 05). A negative correlation was found between the expression of Livin and that of Samc in breast cancer (P<0. 05). The 5-year disease free survival (DFS) of the Livin-negative group (66. 7% ) was significantly longer than that of the Livin-positive group (23. 5% , P<0. 05), while the 5-year DFS of the Smac-negative group and that of the Smac-positive group were not significantly different ( P >0. 05). Conclusion: The expression level of Livin in breast cancer tissue is negatively related to the expres- sion level of Smac in breast cancer tissue, indicating a negative correlation between these two proteins. meanwhile, the 5 year DFS of Livin-negative patients is significantly longer than that of the Livin-positive patients. Therefore, Livin may be employed as a prognosis indicator for breast cancer patients.关键词
乳腺癌/Livin/Smac/临床意义Key words
Breast cancer/Livin/Smac/Clinical significance分类
医药卫生引用本文复制引用
Xu Nie,Li Changlin,Xiao minwei,Hou mei..乳腺癌组织中Livin和Smac的表达及其临床意义[J].肿瘤预防与治疗,2019,32(4):324-330,7.基金项目
四川省卫生厅科研课题(编号:110001) This study was supported by grants from Health Commission of Sichuan Province (NO. 110001) （编号:110001）
