肿瘤预防与治疗2019，Vol.32Issue(4)：331-335,5.DOI:10. 3969/j. issn. 1674-0904. 2019. 04. 007
经鼻内镜下治疗侵及眼眶的鼻腔鼻窦恶性肿瘤36例临床分析
Endoscopic Transnasal Surgery for Nasal Cavity and Paranasal Sinus Ma-lignant Tumors Involving Orbit: Clinical Analysis of 36 Cases
摘要
Abstract
Objective: To analyze the effect of endoscopic transnasal surgery in the treatment of nasal cavity and paranasal sinus malignant tumors involving orbit, and explore the related factors affecting the prognosis. Methods: Clinical data of 36 cases of nasal cavity and paranasal sinus malignant tumors in-volving orbit who underwent surgical treatment in Sichuan Pro-vincial People’s Hospital between January 2010 and Decem- ber 2017 were reviewed retrospectively. The 5-year survival rate, recurrence rate and complications were followed up, and the related risk factors affecting the prognosis of the patients were discussed. Results: In this group of 36 patients, 2 patients were lost, and the follow-up completion rate was 94. 4% ; 34 patients were followed up for 8 to 76 months, with a median fol-low-up of 26 months, and a mean follow-up of (27. 2 ± 18. 6) months; follow-up was conducted among 13 cases during the period of tumor recurrence, and the recurrence rate was 36. 1% . The 1-year, 3-year, and 5-year overall survival (OS) were 86. 1% , 75. 0% , and 52. 8% , respectively. The median OS of phase Ⅰ~Ⅲ patients were 60 months, 20 months and 16 months, respectively. There was statistically significant difference in the survival curves among patients with clinically differ-ent stages (χ2 =4. 252, P=0. 039). The median OS of squamous cell carcinoma patients, adenoid cystic carcinoma pa-tients, sarcoma patients and other malignant tumor patients were 19, 36, 11 and 49 months. The difference in survival curves among patients with different pathological types was not statistically significant (χ2 =3. 736; P=0. 291). Multivariate Cox regression analysis showed that clinical stage was an independent risk factor affecting patients’ outcomes (P<0. 05). Conclusion: Endoscopic transnasal surgery for nasal cavity and paranasal sinus malignant tumors involving orbit is effective. The prognosis of patients is closely related to clinical stage.关键词
鼻腔肿瘤/鼻窦肿瘤/鼻内镜手术/眼眶Key words
Nasal cavity neoplasms/Paranasal sinus neoplasms/Endoscopic transnasal surgery/Orbit分类
医药卫生引用本文复制引用
Zhang Jing,Gu Qingjia,Yu Wenxing,Shui Lei,Yang Yu..经鼻内镜下治疗侵及眼眶的鼻腔鼻窦恶性肿瘤36例临床分析[J].肿瘤预防与治疗,2019,32(4):331-335,5.基金项目
成都市科技局科技惠民技术研发项目(编号:2015-Hm01-0017-SF) This study was supported by grants from Science and Technology Bureau of Chengdu ( NO. 2015-Hm01-0017-SF) . （编号:2015-Hm01-0017-SF）
