肿瘤预防与治疗2019，Vol.32Issue(4)：366-371,6.DOI:10. 3969/j. issn. 1674-0904. 2019. 04. 014
IL-33/ST2 途径在肿瘤发生和发展中作用的研究进展
Advances in the Role of IL-33/ST2 Pathway in Tumorigenesis and Tumor Progression
摘要
Abstract
Interleukin-33 (IL-33) is a new member of the IL-1cytokine family found in recent years. It can function as both intracellular transcription factors and extracellular cytokines. IL-33 and its receptor ST2 mediate a variety of physiologi-cal and pathological conditions, such as chronic inflammation, autoimmune diseases, allergic immune response andtissue re-pair. In recent years, there are a large number of studies showing that IL-33 is closely related to the occurrence and develop-ment of tumors, but the mechanism of its precise role in tumorigenesis and tumor immune response has not yet been clearly illustrated. In this review, the role of IL-33/ST2 in tumorigenesis, tumor development and tumor microenvironment in recent years is reviewed, in order to provide a new strategy forusing IL-33 as a target for tumor diagnosis and immunotherapy.关键词
IL-33/ST2/Th1型免疫应答/Th2型免疫应答/肿瘤微环境Key words
IL-33/ST2/The 1 type immune response/The 2 type immune response/Tumor microenvironment分类
医药卫生引用本文复制引用
Hu Xia,Shan Jing,Sun Xiaobin..IL-33/ST2 途径在肿瘤发生和发展中作用的研究进展[J].肿瘤预防与治疗,2019,32(4):366-371,6.基金项目
成都市卫计委基金资助项目(编号:2015003) （编号:2015003）
成都市科技局课题(编号:2015-Hm01-00377-SF) This study was supported by grants from Chengdu Health Planning Commission ( NO. 2015003 ) and Chengdu Science and Technology Brueau ( NO. 2015-Hm01-00377-SF) . （编号:2015-Hm01-00377-SF）
