肿瘤预防与治疗2019，Vol.32Issue(5)：402-408,7.DOI:10. 3969/j. issn. 1674-0904. 2019. 05. 004
中性粒细胞/淋巴细胞比值对早期原发乳腺弥漫大 B细胞淋巴瘤的临床特征及预后的影响*
Effect of NeutroPhiI to LymPhocyte Ratio on CIinicaI Features and Prognosis of Patients With EarIy Primary Breast Diffuse Large B-ceII LymPhoma
摘要
Abstract
To ana1yze the effect of neutroPhi1 to 1ymPhocyte ratio ( NLR ) on c1inica1 features and Prognosis of Patients with ear1y Primary Breast Diffuse Large B-ce11 LymPhoma (PB-DLBCL). Methods: C1inica1 data of 45 cases of ear1y PB- DLBCL in Sichuan Cancer HosPita1 from SePtember 2005 to SePtember 2015 were retrosPective1y ana1yzed. The abso1ute neutroPhi1s and 1ymPhocytes in the comP1ete b1ood ce11 count of the Patients before treatment were counted, and the NLR was ca1cu1ated. The KaP-1an-Meier method was used for surviva1 ana1ysis. Univariate ana1ysis was Performed with Log-rank test and mu1tivariate ana1ysis was Performed with the Cox-regression mode1. ResuIts: Of the 45 Patients with PB-DLBCL, most Patients were fema1es (97. 8% ). The median age was 45 years (28~77 years). The ma1e to fema1e ratio was 1:44. A11 Patients had Pain1ess breast mass as the first symP-tom, it occurred in the right breast in 29 cases and in the 1eft breast in 16 cases. B symPtoms occurred in 5 cases. A11 Patients received chemotheraPy, 31 Patients received Rituximab immunochemotheraPy, 12 Patients received 1oca1 radiation theraPy, and 14 Patients re-ceived ProPhy1actic intratheca1 chemotheraPy. As for the Patho1ogica1 subtyPe (Hans c1assification criteria), 10 Patients were diag-nosed with germina1 center B-ce11 tyPe ( GCB tyPe) and 35 Patients were diagnosed with non-germina1 center B-ce11 tyPe ( non-GCB tyPe). The median fo11ow-uP time was 97 months. The median Progression-free surviva1 has not been reached. The median overa11 sur-viva1 was 38 months (12~78 months) and 3-year overa11 surviva1 rate for the 45 PB-DLBCL cases was 68. 9% . The oPtima1 cut off va1ue of 3. 211 for NLR was obtained by the ROC ana1ysis and the Patients were divided into two grouPs, 1ow NLR grouP (≤3. 211) and high NLR grouP (>3. 211). NLR was significant1y associated with Hans tyPing (P=0. 02), site of 1esion (P=0. 015) and IPI score (P=0. 002). The univariate ana1ysis showed that non-GCB (P=0. 011), stage Ⅱ(P=0. 038), ECOG score ≥2 (P=0. 002), IPI score ≥2 (P=0. 002), NLR va1ue>3. 211 ( P =0. 007) and no Preventive intratheca1 chemotheraPy ( P=0. 002) were factors that affect the Prognosis in Patients with PB-DLBCL; mu1tivariate ana1ysis showed that ECOG score, IPI score, NLR and ProPhy1actic intratheca1 chemotheraPy were indePendent risk factors (P < 0. 05). ConcIusion: NLR has a corre1ation with the c1inica1 features of PB-DLBCL, and it may be an imPortant indePendent Prognostic factor of Patients with PB-DLBCL.关键词
早期/原发乳腺弥漫大B细胞淋巴瘤/NLR/临床特征/预后 IPI评分/预防性鞘内化疗Key words
Ear1stage/Primarbreast diffus1argB-ce11 1ymPhoma/NLR/C1inica1 features/Prognosis/IPI score/ProPhy1ac-tic intratheca1 chemotheraPy引用本文复制引用
Yao Wanzhi,Wu Ping,Zhang Zhihui,Feng Weizhen,Ouyang Chutong,Peng Xiaoqin,Wei Wen,Ren Yuanrong,Yu Sisi,Li Renqin,Li Li..中性粒细胞/淋巴细胞比值对早期原发乳腺弥漫大 B细胞淋巴瘤的临床特征及预后的影响*[J].肿瘤预防与治疗,2019,32(5):402-408,7.基金项目
四川省卫生厅科研基金资助项目(编号:090528) This study was suPPorted by grants from Hea1th DePartment of Sichuan Province (NO. 090528). （编号:090528）
