肿瘤预防与治疗2019，Vol.32Issue(5)：409-414,6.DOI:10. 3969/j. issn. 1674-0904. 2019. 05. 005
基于公共数据库分析脯氨酸羟化酶3在非小细胞肺癌中的表达及预后价值
ExPression and Prognostic VaIue of PHD3 in Non-SmaII CeII Lung Cancer: An AnaIysis Based on Data from PubIic Database
Qin Yuan 1Hang Dandan 1Fu Binyu 1Luo Yangkun1
作者信息
- 1. DePartment of Radiation Oncology, Sichuan Cancer HosPital & Institute, Sichuan Cancer Center, School of Medi-cine, UniVersity of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China
- 折叠
摘要
Abstract
To investigates the exPression and Prognostic va1ue of Pro1y1 hydroxy1ase 3 ( PHD3) in non-sma11 ce11 1ung cancer(NSCLC). Methods: Oncomine and Gene ExPression Omnibus (GEO) databases were used to determine the exPression 1eve1 of PHD3 mRNA in NSCLC. The exPression 1eve1 and Prognostic va1ue of PHD3 mRNA was determined by KaP1an-Meier P1otter and SurvExPress database. ResuIts: The exPression 1eve1s of PHD3 mRNA were significant1y uP-regu1ated in NSCLC comPared with norma1 tissue (P=0. 028). High exPression 1eve1 of PHD3 was associated with 1ung squamous ce11 carcinoma (LUSC), advanced stages and ma1e Patients (P<0. 001,P=0. 001;resPective1y). The resu1ts of KaP1an-Meier P1otter revea1ed that the high PHD3 exPression grouP exhibited Poorer surviva1 in 1ung adenocarcinoma ( LUAD) Patients( P =0. 003). The SurvExPress ana1ysis a1so showed that PHD3 main1y affected the Prognosis of LUAD Patients ( P=0. 013), and that PHD3 exPression was significant1y e1evated in the high-risk grouP (P<0. 001). KaP1an-Meier P1otter and SurvExPress ana1yses suggested that PHD3 mRNA exPression was not associated with sur-viva1 in LUSC Patients. ConcIusion: PHD3 might serve as a Potentia1 biomarker to Predict surviva1 of NSCLC, main1y of LUAD.关键词
脯氨酸羟化酶3/非小细胞肺癌/预后/mRNAKey words
Pro1y1 hydroxy1as3/Non-sma11 ce11 1ung cancer/Prognosis/mRNA引用本文复制引用
Qin Yuan,Hang Dandan,Fu Binyu,Luo Yangkun..基于公共数据库分析脯氨酸羟化酶3在非小细胞肺癌中的表达及预后价值[J].肿瘤预防与治疗,2019,32(5):409-414,6.
