肿瘤预防与治疗2019，Vol.32Issue(5)：415-420,6.DOI:10. 3969/j. issn. 1674-0904. 2019. 05. 006
ADC值评估早期宫颈癌淋巴管侵犯的价值*
VaIue of APParent Diffusion Coefficient VaIue in EvaIuating LymPhatic Invasion in EarIy CervicaI Cancer
摘要
Abstract
To investigate the diagnostic va1ue of different aPParent diffusion coefficients (ADC), which inc1ude Tumor-ADCmean va1ues, Tumor-ADCmin va1ues, Peritumora1 ADC ( Peritum-ADC) va1ues and ADC-norma1ized va1ues ( Peritum-ADC va1ues/Tumor-ADCmin va1ues),on 1ymPhovascu1ar invasion (LVI) in ear1y cervica1 cancer. Methods: The c1inica1 and magnetic resonance signs of 81 Patients with ear1y cervica1 cancer in our hosPita1 were retrosPective1y ana1yzed. The Patho1ogica1 resu1ts were regarded as the go1d standard. The Patients were divided into two grouPs, the LVI Positive grouP and the LVI negative grouP, according to Patho- 1ogica1 resu1ts. Differences in Tumor-ADCmean va1ues, Tumor-ADCmin va1ues, Peritum-ADC va1ues and ADC-norma1ized va1ues between the two grouPs were comPared,and the diagnostic efficacy of different ADC va1ues for LVI in cervica1 cancer was ca1cu1ated. ResuIts: Of 81 Patients with ear1y cervica1 cancer, 26 were LVI Positive and 55 were LVI negative. There were no statistica11y significant differences in age and histo1ogica1 tyPe between the two grouPs (P >0. 05), but there were statistica11y significant differences in tumor diameter, dePth of muscu1ar invasion, Internationa1 Federation of Gyneco1ogy and Obstetrics stage and 1ymPh node status ( P <0. 05). There were no statistica11y significant differences in Tumor-ADCmean va1ues and Peritum-ADC va1ues between the two grouPs (P>0. 05), but differences in Tumor-ADCmin va1ues and ADC-nor-ma1ized va1ues were statistica11y significant (P <0. 05). The Tumor-ADCmin va1ue in the LVI Positive grouP was 1ower than that in the LVI negative grouP [t=5. 307, P<0. 001,(0. 76 ± 0. 15)×10 -3mm2/s Vs (0. 97 ± 0. 18)×10 -3 mm2/s, resPective1y]. The ADC-norma1ized va1ues in the LVI Positive grouP was higher than that in the LVI negative grouP [t= -6. 803, P<0. 001, (2. 02 ± 0. 29) Vs (1. 53 ± 0. 31), resPective1y]. Receiver oPerating curve showed that the efficiency of ADC-norma1ized va1ues was better than that of Tumor-ADCmin va1ues (Z=2. 202, P=0. 028) in diagnosing LVI Positive ear1y cervica1 cancer. Area under curve was 0. 833 Vs 0. 922, resPective1y. ConcIusion: LVI Positive is re1ated to many ma1ignant bio1ogica1 behaviors of ear1y cervica1 cancer. ADC va1ues, esPe-cia11y ADC-norma1ized va1ues, are high1y va1uab1e in diagnosing LVI Positive ear1y cervica1 cancer.关键词
ADC值/早期宫颈癌/淋巴管侵犯Key words
ADC va1ues/Ear1cervica1 cancer/LymPhovascu1ainvasion引用本文复制引用
Xu Xiaoxi,Han Yun,Wang Peng,Zhang Wei,Song Qiong..ADC值评估早期宫颈癌淋巴管侵犯的价值*[J].肿瘤预防与治疗,2019,32(5):415-420,6.基金项目
湖北省卫生健康委员会科研项目(编号:WJ2019M026 ) This study was suPPorted by grants from Hea1th Commission of Hubei Province (NO. WJ2019M026) . （编号:WJ2019M026 ）
