|国家科技期刊平台
| 注册
首页|期刊导航|肿瘤预防与治疗|肿瘤体积及瘤体缩减率在同步放化疗的宫颈癌患者预后中的价值*

肿瘤体积及瘤体缩减率在同步放化疗的宫颈癌患者预后中的价值*

Sun Chang Lu Shun Zhang Hanyi Zhang Jiayu Wang Ran1in Tan Mingyu Lang Jinyi

肿瘤预防与治疗2019，Vol.32Issue(5)：421-428,8.
✕
肿瘤预防与治疗2019，Vol.32Issue(5)：421-428,8.DOI:10. 3969/j. issn. 1674-0904. 2019. 05. 007

肿瘤体积及瘤体缩减率在同步放化疗的宫颈癌患者预后中的价值*

Prognostic VaIue of Tumor VoIume and Tumor VoIume Reduction Rate during Concurrent ChemoradiotheraPy in Patients With CervicaI Cancer

Sun Chang 1Lu Shun 2Zhang Hanyi 1Zhang Jiayu 2Wang Ran1in 1Tan Mingyu 2Lang Jinyi1

作者信息

  • 1. School of Clinical Medicine, Southwest Medical UniVersity, Luzhou 646000, Sichuan, China
  • 2. Sichuan Cancer HosPital & Institute, Sichuan Cancer Center, School of Medi-cine, UniVersity of Electronic Science and Technology of China, Chengdu 610041, Sichuan, China
  • 折叠

摘要

Abstract

To investigate the Prognostic va1ue of changes in Primary tumor vo1ume Parameters after externa1 beam radiotheraPy in Pa-tients with 1oca1 advanced cervica1 cancer. Methods: A tota1 of 217 women with cervica1 cancer who received radica1 concurrent chemo-radiotheraPy (CCRT) based on intensity modu1ated radiation theraPy and high dose rate intracavitary brachytheraPy were retrosPective1y ana1yzed. The Primary tumor vo1ume and size were measured Pre-radiotheraPy and mid-radiotheraPy by Pe1vic magnetic resonance ima-ging. Overa11 surviva1 (OS), Progression free surviva1 (PFS) and 1oca1 fai1ure-free surviva1 (LFFS) were estimated. Resu1ts: The 5- year OS, PFS and LFFS rates of Patients were 81. 3% , 85. 1% and 92. 9% , resPective1y. The median fo11ow-uP time was 51 months. Mu1tivariate ana1ysis revea1ed that tumor Parameters inc1uding Inter-nationa1 Federation of Gyneco1ogy and Obstetrics stage >Ⅱ( P=0. 029), Pre-radiotheraPy tumor vo1ume >61. 6cm3 (P =0. 032) and mid-radiotheraPy tumor vo1ume>11. 38cm3 (P=0. 034) were significant1y associated with a worse OS. In univariate ana1ysis, tumor vo1ume reduction rate (TVRR) was significant associated with OS (P<0. 001) and LFFS ( P=0. 050). Conc1usion: TVRR and mid-radiotheraPy tumor vo1ume are va1uab1e Prognostic factors for Patients with 1oca1 advanced cervica1 cancer receiving CCRT.

关键词

宫颈癌/肿瘤体积/瘤体缩减率/放射敏感性/同步放化疗

Key words

Cervix cancer, Tumovo1ume/Tumovo1umreduction rate/Radiosensitivity/Concurrent chemoradiotheraPy

引用本文复制引用

Sun Chang,Lu Shun,Zhang Hanyi,Zhang Jiayu,Wang Ran1in,Tan Mingyu,Lang Jinyi..肿瘤体积及瘤体缩减率在同步放化疗的宫颈癌患者预后中的价值*[J].肿瘤预防与治疗,2019,32(5):421-428,8.

基金项目

四川省科技厅项目(编号: 2015SZ0053、2017HH0096) This study was suPPorted by grants from Science & Techno1ogy DePartment of Sichuan Province ( NO. 2015SZ0053, NO. 2017HH0096). （编号: 2015SZ0053、2017HH0096）

肿瘤预防与治疗

OACSTPCD

1674-0904

访问量0
|
下载量0
段落导航相关论文