YANG Mei 1RUAN Chao 2CHEN Jingju2
作者信息
- 1. Department of Neurology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004,China
- 折叠
摘要
Abstract
Objective To investigate the short-term and long-term effects of endovascular interventional therapy and drug therapy on cerebral watershed infarction with severe stenosis of the responsible artery. Methods We retrospectively analyzed 195 cases of cerebral watershed infarction (CWI). According to different treatments,patients were divided into in-terventional treatment group (87 cases) and drug treatment group (108 cases). In the interventional group,patients were treated with interventional therapy in the intracranial artery or middle cerebral artery M1 segment within 2 weeks of oneset, also were given antiplatelet and statin drugs;while the patients in the drug treatment group was only given antiplatelet and statin. Follow-up by telephone,we compared the NIHSS scores at 3 months,6 months,and 1 year as well as mRS at 3 months,6 months,1 year,2 years,and 5 years after discharge between the two groups. Besides,we compared the occur-rences of cerebral hemorrhage,cerebral infarction,TIA,and death during the follow-up period. Results (1)The decline of NIHSS scores was significantly different between the two groups at 3 months after discharge (P=0. 008);(2)The propor-tion of patients with mRS ≤2 was significantly higher of the interventional group than the drug-treated group at 3 months, 6 months,5 years and at the end of follow-up after discharge(P=0. 037,0. 035,0. 035,and 0. 022,respectively);(3) The recurrence rate of ipsilateral ischemic stroke of the endovascular intervention group was significantly lower than the drug-treated group at 1 year,2 years,5 years,and at the end of follow-up after discharge(P=0. 049,0. 049,0. 03,and 0. 017,re-spectively);(4)There was no difference in the total mortality and the proportion of patients who died of cerebral infarction between two groups during the follow-up period (P=0. 723,0. 505,respectively). Conclusion For cerebral watershed in-farction patients,compared with drug therapy alone,early endovascular intervention could significantly promote the recovery of neurological function,reduce disability,improve the prognosis of patients,and prevent the recurrence rate of long-term cerebral infarction and transient ischemic attack.关键词
分水岭脑梗死/介入治疗/效果/远期Key words
Watershedcerebralinfarction/Interventionaltherapy/Effect/Long-term分类
医药卫生
