中风与神经疾病杂志2019，Vol.36Issue(6)：496-500,5.
CD19+CD24high CD38high调节性B细胞及相关细胞因子在视神经脊髓炎谱系疾病患者外周血中的变化及意义
The study of CD19 +CD24highCD38high regulatory B cells and related cytokines in the spectrum of optic nerve myeli-tis
DONG Mei 1SHI Xiaohe 2WANG Wei1
作者信息
- 1. Department of Neurology,Key Laboratory of Neurology of Hebei Province, The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China
- 折叠
摘要
Abstract
Objective The levels of CD19 +CD24high CD38high Breg,IL-10 and TGF-beta in peripheral blood of pa-tients with NMOSD were analyzed,and the role of CD19 +CD24high CD38high Breg in the acute phase of NMOSD was dis-cussed. The level of GFAP in peripheral blood of NMOSD patients was detected and the correlation between GFAP and the severity of the disease was discussed with the EDSS score. Methods From December 2016 to 2018 01,27 patients in the acute phase of NMOSD in the Second Hospital of Hebei Medical University were selected as the experimental group,and 20 healthy persons matched for sex and age were selected as control group. The EDSS score and flow cytometry were used to de-tect the number of CD19 +CD24high CD38high Breg in peripheral blood of NMOSD patients. The levels of IL-10,TGF-and GFAP in peripheral blood were detected by PCR and compared with healthy persons. Results The level of CD19 +CD24high CD38high Breg in group of NMOSD was lower than that in the control group,and the difference was statistically significant. There was no linear relationship between Bregs and EDSS score. The levels of IL-10 and TGF-beta in group of NMOSD were lower than that in the control group,and the difference was statistically significant. The level of GFAP in group of NMOSD was higher than that in the control group,and there was a significant difference between the two groups. There is no linear relationship between GFAP and EDSS. Conclusion CD19 +CD24highCD38high Breg was not only significantly reduced in the pathogenesis of NMOSD,but also significantly impaired in its function. The serum GFAP increased but it has no relationship with EDSS in relapsed NMOSD patients.关键词
视神经脊髓炎谱系疾病/白介素10/转化生长因子-β/胶质纤维酸性蛋白Key words
Optic neuromyelitis spectrum disease/Lnterleukin-10/Transforming growth factor beta/B cell acti-vating factor/Glial fibrillary acidic protein分类
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DONG Mei,SHI Xiaohe,WANG Wei..CD19+CD24high CD38high调节性B细胞及相关细胞因子在视神经脊髓炎谱系疾病患者外周血中的变化及意义[J].中风与神经疾病杂志,2019,36(6):496-500,5.
