中风与神经疾病杂志2019，Vol.36Issue(6)：527-530,4.
血浆microRNA-135 a及microRNA-210在轻度认知损害患者中的检测价值
The detection of plasma microRNA-135a and microRNA-210 in the patient of mild cognitive impairment
摘要
Abstract
Objective To evaluate the clinical value of plasma microRNA-135a,microRNA-210 in the detection of mild cognitive impairment. Methods The plasma samples of 80 subjects were collected from our hospital. There were 28 people with VD-MCI,24 people with AD-MCI and 28 age-matched control(AMC). RT-qPCR was applied to test the level of microRNA-135a and microRNA-210. Results The levels of microRNA-135a in plasma were ( 4. 17 ×10 -7 ± 8. 35 × 10 -8),(2. 83×10 -7 ± 1. 72 ×10 -7 ) and (9. 87 ×10 -7 ± 5. 66 ×10 -7 ) in VD-MCI,AD-MCI and AMC. There were difference among three groups(F=30. 76,P=0. 00,P<0. 05). The levels of microRNA-210 in plasma were(4. 27×10 -5 ± 1. 09×10 -5),(6. 96×10 -5 ± 2. 48×10 -5 ) and (1. 30×10 -5 ± 7. 07×10 -6 ) in VD-MCI,AD-MCI and AMC. There were difference among three groups(F=80. 43,P=0. 00,P<0. 05). There were no correlations between the MMSE score and the two biomarkers(P>0. 05). Conclusions The plasma microRNA-135a and microRNA 210 were potential biomark-ers of MCI,especially for AD-MCI.关键词
轻度认知损害/微小RNA/生物标志物Key words
Mild cognitive impairment(MCI)/MicroRNA/Biomarker分类
临床医学引用本文复制引用
HU Yi-hong,BAI Chunyan,LI Zongshu..血浆microRNA-135 a及microRNA-210在轻度认知损害患者中的检测价值[J].中风与神经疾病杂志,2019,36(6):527-530,4.基金项目
吉林省自然科学基金(No. 20160101178JC) （No. 20160101178JC）
