中国卒中杂志2019，Vol.14Issue(3)：207-212,6.DOI:10.3969/j.issn.1673-5765.2019.03.003
血尿酸水平与急性缺血性卒中病情严重程度和预后的关系研究
Association of Serum Uric Acid Level with Stroke Severity and Prognosis in Patients with Acute Ischemic Stroke
摘要
Abstract
Objective To investigate the relationship between serum UA level and stroke severity and prognosis of acute ischemic stroke (AIS). Methods Data of consecutive AIS patients from Shenzhen Second People's Hospital during January 2014 to December 2017 were retrospectively collected. According to UA tertile levels, all patients were divided into three groups: low-level group (3.85-298.80) μmol/L, moderate-level group (299.80-398.00) μmol/L and high-level group (402.30-702.10) μmol/L. Multivariate regression analysis was used to analyze the risk factors of stroke severity and prognosis in AIS patients. Stratified analysis was used to analyze the relationship between serum UA levels and stroke severity and clinical prognosis in different risk stratification subgroups. Results Among the total 227 patients, 75 cases in low-level group, 72 cases in moderate-level group and 80 cases in high-level group. After adjusting the confounding factors, comparing with the low-level group, the NIHSS score at admission decreased by 2.16 points (β-2.16, 95% CI-3.53--0.78, P=0.002) and the rate of early neurological deterioration (END) decreased by 60% ( OR 0.40, 95% CI 0.16-0.97, P=0.042) in the high-level group. Stratified analysis result showed that with the increase of serum UA level, the NIHSS score at admission (stroke severity) decreased and the short-term clinical prognosis were better in male and newly diagnosed stroke patients. Conclusions The serum UA level was associated with stroke severity and END in AIS patients, especially in male and newly diagnosed stroke patients.关键词
缺血性卒中/尿酸/神经功能缺损/氧化应激/预后Key words
Ischemic stroke/Uric acid/Neurological deficit/Oxidativstress/Prognosis引用本文复制引用
WANG Yun-Yun,XIE Xiao-Hua,REN Li-Jie,YANG-Mei,PAN Lu,YAN Feng-Xian,ZHANGJian,DENG Li-Ping,XIONG Xiao-Yun..血尿酸水平与急性缺血性卒中病情严重程度和预后的关系研究[J].中国卒中杂志,2019,14(3):207-212,6.基金项目
广东省科学技术厅资助项目(2017A020215121)广东省卫生经济学会项目(2017-WJ02-08)深圳市第二人民医院临床研究项目(20173357201830)深圳市科技创新委员会项目(CXZZ201404181826 38768)深圳市科技创新委员会项目(JCYJ201604250942 26228 （2017A020215121）
JCYJ20170306092 024314) （）
