CHAI Xiang-Ting 1WANG Xiang-Xiang 1ZHANG Rui-Xia 1MA Ling-Li 1XIAO Xing 1WANG Yan 2TAN Lan3
作者信息
- 1. Department of Neurology, People’s Hospital of Qingdao West Coast New Area, Qingdao 266400, China
- 2. Department of Neurology, Qingdao University Affiliated Hospital, Qingdao 266071, China
- 3. Department of Neurology, Qingdao Municipal Hospital, Qingdao 266011, China
- 折叠
摘要
Abstract
Objective To investigate the imaging characteristics of gait disorders in cerebral small vessel disease (CSVD). Methods This study consecutively enrolled patients with CSVD from neurology department of People’s Hospital of Qingdao West Coast New Area from July 2018 to September 2018. Baseline data were collected including gender, age, chief complaints, smoking, hypertention, hyperlipidemia (HLP), HbA1c, silent brain infarction, periventricular white matter hyperintensities (PWMHs), deep white matter hyperintensities (DWMHs), cortex atrophy (sylvian fissure ratio), subcortex atrophy (caudate head interval ratio), hippocampus atrophy (interuncal distance ratio). Impaired gait was defined as the Holden functional ambulation classification (FAC) score ≤3, and all patients were divided into low risk of falling group (LRF) and high risk of falling group (HRF). Univariate analysis and multivariate Logistic regression analysis were used to identify the independent risk factor of severe gait disorders. Results A total of 102 CSVD patients were identified, including 59 cases (57.8%) in HRF group. Univariate analysis showed that age (P<0.001), HbA1c (P=0.007), PWMHs (P=0.002), DWMHs (P<0.001), sylvian fissure ratio (P<0.001), caudate head interval ratio (P=0.003) and hippocampus interuncal distance ratio (P<0.001) were correlated with tumble. Multivariate Logistic regression analysis showed that age ( OR 1.173, 95% CI 1.053-1.306, P=0.004), DWMHs ( OR 8.883, 95% CI 2.674-29.512, P<0.001) and sylvian fissure ration (OR 1.433, 95% CI 1.028-1.999, P=0.034) were independent risk factors of tumble in CSVD. Conclusions Advanced age, high score of DWMHs and obvious cortex atrophy were independent risk factors of tumble in CSVD, and patients with such risk factors should be paid more attention to prevent tumble.关键词
脑小血管病/步态障碍/危险因素Key words
Cerebral small vessel disease/Gait disorders/Risfactor
