中国卒中杂志2019，Vol.14Issue(3)：231-239,9.DOI:10.3969/j.issn.1673-5765.2019.03.007
癫痫患者动态脑血流自动调节功能研究
Compromised Dynamic Cerebral Autoregulation in Patients with Epilepsy
摘要
Abstract
Objective The aim of this study is to analyze dCA in patients with epilepsy. Methods One hundred patients with epilepsy and 100 age- and sex-matched healthy controls were recruited. Noninvasive continuous cerebral blood flow velocity of the bilateral middle artery and arterial blood pressure were recorded. Transfer function analyses were used to analyze the autoregulatory parameters (phase difference and gain). Results The overall phase difference of patients with epilepsy was significantly lower than that of the healthy control group (P=0.046). Furthermore, patients with interictal slow wave had significant lower phase difference than the slow-wave-free patients (P=0.012). There was no difference in overall phase between focal discharges and multifocal discharges in patients with epilepsy. Simultaneously, there was no difference in mean phase between the affected and unaffected hemispheres in patients with unilateral discharges. In particular, interictal slow wave was an independent factor that influenced phase difference in patients with epilepsy (P=0.016). Conclusions Our study documented that dCA is impaired in patients with epilepsy, especially in those with interictal slow wave. The impairment of dCA occurs irrespective of the discharge location and type. Interictal slow wave is an independent factor to predict impaired dCA in patients with epilepsy. Clinical Trial Identifier This trial is registered with NCT02775682.关键词
癫痫/脑血流自动调节/传递函数/经颅多普勒Key words
Epilepsy/Cerebral autoregulation/Transfefunction/Transcranial Doppler引用本文复制引用
LYU Shan,YANG Yi,GUO Zhen-Ni,JIN Hang,SUN Xin,JIA Mei-Yan,MA Hong-Yin,LYU Yu-Dan,QIU Quan-Li,LIU Jia..癫痫患者动态脑血流自动调节功能研究[J].中国卒中杂志,2019,14(3):231-239,9.基金项目
国家重点研发计划重点专项(2016YFC1301600, 2016YFC1301603)国家自然科学基金(81571123) （2016YFC1301600, 2016YFC1301603）
