中国卒中杂志2019，Vol.14Issue(4)：341-345,5.DOI:10.3969/j.issn.1673-5765.2019.04.008
丁苯酞对轻度血管性认知障碍患者执行功能的影响
Effect of Butylphthalide on Executive Function of Patients with Mild Vascular Cognitive Impairment
BAI YanYan 1KONG Yu 1ZHOU GuoQing 1LU QiangBin 1ZHU ZuFu.1
作者信息
- 1. Department of Neurology, Jiangyin People's Hospital Affiliated to Southeast University, Jiangyin 214400, China
- 折叠
摘要
Abstract
Objective To evaluate the effect of butylphthalide on executive function in patients with mild vascular cognitive impairment (MVCI). Methods A total of 48 MVCI patients were included in this study, all of whom were divided into observation group (n=24) and control group (n=24). On the base of conventional therapy, Butylphthalide (200 mg, tid) was added to the observation group, and Vitamin E (100 mg, tid) was added to control group, with a treatment course of 90 days in each group. Executive function of patients were evaluated by the following tests: trail making test A and B (TMT-A and B), digit span test (including forward and backward), verbal fluency test (VFT) and clock drawing task. Executive function changes of two groups before and after treatment between the two groups were compared to evaluate the effect of butylphthalide on executive function in MVCI patients. Results The baseline cognition and executive function of two groups had no statistical difference. After treatment, the TMT-A [(53.65±0.88) vs (56.22±0.87)] and TMT-B [(174.95±1.99) vs (177.41±1.44)] scores in observation group were significantly lower than that in control group, the digit span forward and backward score [(5.05±1.22) vs (4.59±0.33)] and the VFT score [(13.29±0.88) vs (12.43±1.02)] in observation group were significantly higher than that in control group. There was no statistical difference in CDT between the two groups. Conclusions Butylphthalide can improve the executive function of patients with MVCI.关键词
轻度血管性认知障碍/丁苯酞/执行功能Key words
Mild vascular cognitive impairment/Butylphthalide/Executive function引用本文复制引用
BAI YanYan,KONG Yu,ZHOU GuoQing,LU QiangBin,ZHU ZuFu...丁苯酞对轻度血管性认知障碍患者执行功能的影响[J].中国卒中杂志,2019,14(4):341-345,5.
