中国卒中杂志2019，Vol.14Issue(5)：422-426,5.DOI:10.3969/j.issn.1673-5765.2019.05.004
腔隙性脑梗死认知功能障碍与颈动脉粥样硬化性斑块关系的研究
Relationship between Cognitive Impairment in Lacunar Infarction and Carotid Atherosclerotic Plaque
摘要
Abstract
Objective To investigate the relationship between cognitive impairment in lacunar infarction (LI) and carotid atherosclerotic plaque. Methods A retrospective analysis of 171 patients who met the LI diagnostic criteria in the Department of Neurology, Haidian Hospital from January 2017 to November 2018, and had baseline MoCA scores, were divided into cognitive impairment group and non-cognitive impairment group. Carotid ultrasonography were performed in all patients to observe carotid plaques. Multivariate Logistic regression was used to analyze the relationship between carotid atherosclerotic plaque and cognitive impairment. Results After adjusting for potential confounders, the incidence of cognitive impairment was higher in patients with ≥2 carotid atherosclerotic plaques compared with patients without carotid atherosclerotic plaque ( OR 2.843, 95% CI 1.301-6.216, P=0.008). Patients with≥2 carotid arteries with atherosclerotic plaque had a higher incidence of cognitive impairment ( OR 2.899, 95% CI 1.311-6.409, P=0.008). Conclusions The number of carotid atherosclerotic plaque is an independent risk factor of cognitive impairment in LI patients. With the number of atherosclerotic plaques increasing, the risk of cognitive impairment may increase. The number of carotid artery with atherosclerotic plaque is also an independent risk factor of cognitive impairment in LI patients. With the number of carotid artery with atherosclerotic plaque increasing, the risk of cognitive impairment may increase.关键词
腔隙性脑梗死/认知功能障碍/颈动脉斑块/超声Key words
Lacunar infarction/Cognitive impairment/Carotid plaque/Ultrasound引用本文复制引用
YANG Xing-Dong,ZENG Yi-Jun,TANG Xiao-Mei,FENG Yan,SHI Dong-Mei,LIU Lei,YU Feng-Chun..腔隙性脑梗死认知功能障碍与颈动脉粥样硬化性斑块关系的研究[J].中国卒中杂志,2019,14(5):422-426,5.基金项目
海淀医院院级科研基金面上项目资助(KYM2018006) （KYM2018006）
