中国卒中杂志2019，Vol.14Issue(5)：427-431,5.DOI:10.3969/j.issn.1673-5765.2019.05.005
血浆和肽素水平对急性脑出血患者临床结局的预测研究
Predictive Value of Plasma Copeptin for Outcome of Patients with Acute Cerebral Hemorrhage
WANG Jing 1BIAN Li-Heng 1WANG Wen-Juan 1LIU Yan-Fang 1ZHAO Xing-Quan1
作者信息
- 1. Department of Neurology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100070, China
- 折叠
摘要
Abstract
Objective To investigate the predictive value of plasma copeptin in patients with intracranial hemorrhage. Methods Patients with spontaneous cerebral hemorrhage who were hospitalized in Beijing Tian Tan Hospital from January 2011 to May 2012 were consecutively enrolled. Clinical data of patients, such as gender, age, previous history, blood pressure, laboratory test results, imaging information, as well as GCS and NIHSS scores and plama Copeptin levels were collected at admission. The outcome at 30-day and 90-day was assessed by mRS. Logistic regression analysis was used to evaluate the predictive value of plasma copeptin for 30-day mortality and unfavorable prognosis at 90-day. Results A total of 133 patients were included in the study. 9 patients (6.8%) died within 30 days of cerebral hemorrhage. 55 patients (41.4%) had unfavorable functional prognosis at 90-day follow-up. Baseline hematoma volume ( OR 1.06, 95% CI 1.00-1.13, P=0.047) and NIHSS score ( OR 1.21, 95% CI 1.05-1.39, P=0.01) were independent predictors of poor prognosis at 90 days after intracerebral hemorrhage. GCS score ( OR 1.41, 95% CI 1.21-1.63, P=0.03) and plasma Copeptin level ( OR 2.50, 95% CI 1.16-5.37, P=0.02) were independent predictors of 30-day mortality after intracerebral hemorrhage. Conclusions Increased plasma copeptin level is an independent predictive factor of 30-day mortality in patients with spontaneous cerebral hemorrhage.关键词
和肽素/脑出血/预后Key words
Copeptin/Intracerebral hemorrhage/Outcomes引用本文复制引用
WANG Jing,BIAN Li-Heng,WANG Wen-Juan,LIU Yan-Fang,ZHAO Xing-Quan..血浆和肽素水平对急性脑出血患者临床结局的预测研究[J].中国卒中杂志,2019,14(5):427-431,5.
