肿瘤药学2019，Vol.9Issue(1)：56-59,4.DOI:10.3969/j.issn.2095-1264.2019.01.11
胸腺五肽治疗晚期胃癌合并重症肺炎患者的疗效观察
Therapeutic Effects of Thymopentin on Advanced Gastric Cancer Patients Combined with Severe Pneumonia★
摘要
Abstract
Objective To investigate the clinical efficacy of thymopentin for advanced gastric cancer patients with severe pneumonia and its effect on the survival period of patients. Methods Sixty-four cases of advanced gastric cancer with severe pneumonia patients in our hos-pital were randomly divided into control group and observation group, with 32 cases in each group. The control group was given conventional chemotherapy drugs and nutritional support. The observation group was added with thymopentin on the base of treatment in control group. The effective rate, the levels of serum C reactive protein (CRP) and procalcitonin (PCT), the 3-year survival rate after treatment and the quality of life before and after treatment were compared between the two groups. Results The time to tumor progression (TTP) of the obser-vation group was significantly longer than that of the control group (P<0.05). Before treatment, the serum CRP and PCT levels of two groups had no significant differences (P>0.05). But after treatment, they were significantly lower in the observation group than in the control group (P<0.05). The 3-year survival rate of the observation group was significantly higher than that of the control group (P<0.05). There were no significant differences in quality of life scores between the two groups before treatment (P>0.05). After treatment, the quality of life scores in both groups were improved, and that of the observation group was significantly higher than that of the control group (P<0.05). Conclusion Thymopentin had good therapeutic effects on advanced gastric cancer patients with severe pneumonia. It could significantly improve the treatment efficiency, the levels of serum factors, prolong the survival time of patients, and improve the quality of life of patients.关键词
胸腺五肽/晚期胃癌/重症肺炎/治疗有效率/生存期/生活质量评分Key words
Thymopentin/ Advanced gastric cancer/ Severe pneumonia/ Therapeutic efficiency/ Survival/ Quality of life score分类
医药卫生引用本文复制引用
CHEN Shanshan,LIU Fangfang,LIU Zishuang,ZHANG Xinfeng,WEI Li..胸腺五肽治疗晚期胃癌合并重症肺炎患者的疗效观察[J].肿瘤药学,2019,9(1):56-59,4.基金项目
基金项目:国家自然科学基金资助项目(81171435). （81171435）
