肿瘤药学2019，Vol.9Issue(1)：68-71,81,5.DOI:10.3969/j.issn.2095-1264.2019.01.14
脾多肽辅助同步放化疗对局部晚期非小细胞肺癌患者免疫功能的影响
Effects of Lienal Polypeptide-assisted Chemoradiotherapy on Immune Function of Patients with Locally Advanced Non-small Cell Lung Cancer★
摘要
Abstract
Objective To investigate the effects of lienal polypeptide injection as adjuvant concurrent with chemoradiotherapy on T lymphocyte subsets and NK cells in patients with locally advanced non-small cell lung cancer. Methods A total of 114 patients with locally advanced non-small cell lung cancer were divided into observation group and control group. The control group received concurrent chemo-radiotherapy, while the observation group received lienal polypeptide injection and concurrent chemoradiotherapy. The general condition and therapeutic effect of the two groups were compared before and after treatment. The adverse reactions of the two groups were analyzed statistically. The percentage of T lymphocyte subsets and NK cells in peripheral blood lymphocyte was compared between the two groups. Results After treatment, the effective rate of the observation group was significantly higher than that of the control group (P<0.05). As for the control rate, no difference was found between the two groups (P>0.05). The incidence of adverse reactions in the observation group was sig-nificantly lower than that in the control group (P<0.05). Before treatment, there was no significant difference in the KPS scores of the whole body condition between the two groups. After treatment, the KPS scores of both groups were higher than before treatment (P<0.05), and the KPS score of observation group was significantly higher than that of control group (P<0.05). The percentage of T lymphocyte subsets and NK cells in peripheral blood lymphocyte increased significantly. The percentage of CD3+, CD4+ and NK cells in peripheral blood lymphocyte in the observation group was significantly higher than that in the control group (P<0.05). Conclusion The lienal polypeptide -assisted concur-rent chemoradiotherapy could improve the immune function of patients with locally advanced non-small cell lung cancer.关键词
脾多肽/同步放化疗/局部晚期非小细胞肺癌/T淋巴细胞亚群/NK细胞Key words
Lienal polypeptide/ Concurrent chemoradiotherapy/ Locally advanced non-small cell lung cancer/ T lymphocyte subsets/ NK cells分类
医药卫生引用本文复制引用
WANG Ruiheng,LIU Xiaoran,LI Qian,WANG Xiurong,LI Wenyan..脾多肽辅助同步放化疗对局部晚期非小细胞肺癌患者免疫功能的影响[J].肿瘤药学,2019,9(1):68-71,81,5.基金项目
基金项目:国家自然基金青年科学基金(81703055). （81703055）
