肿瘤药学2019，Vol.9Issue(1)：72-75,4.DOI:10.3969/j.issn.2095-1264.2019.01.15
多西他赛联合顺铂及替吉奥在局部晚期鼻咽癌中的近期临床疗效及安全性
The Short-term Clinical Efficacy and Safety of Docetaxel Combined with Cisplatin and S-1 in Locally Advanced Nasopharynx Cancer★
摘要
Abstract
Objective To investigate the short-term clinical efficacy and safety of docetaxel combined with cisplatin and S-1 for locally advanced nasopharynx cancer. Methods A total of 94 patients with locally advanced nasopharynx cancer admitted to our hospital between February 2016 and February 2018 were selected as subjects, and they were randomly divided into the observation group and control group. The control group was treated with docetaxel combined with cisplatin and fluorouracil, while the observation group was treated with docetaxel combined with cisplatin and S-1. The differences were compared between the two groups in clinical short-term efficacy, immune function before and after treatment, and toxic and side effects. Results The short-term total effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the levels of serum IL-12 and IFN-γ were higher in the observation group than in the control group, while the levels of serum MMP-2 were lower in the observation group than in the control group (all P<0.05). No significant differences were found between the observation group and the control group in the incidences of gastrointestinal response, peripheral nerve damage, liver and kidney dysfunction, bone marrow suppression and leukopenia (all P>0.05). Conclusion Docetaxel combined with cispla-tin and S-1 had significant short-term clinical efficacy in the treatment of locally advanced nasopharynx cancer. It could help improve the immune function of patients without increasing the incidence of toxic side effects. So it is safe and worthy of clinical application.关键词
局部晚期鼻咽癌/多西他赛/顺铂/替吉奥/不良反应Key words
Local advanced nasopharynx cancer/ Docetaxel/ Cisplatin/ S-1/ Adverse reactions分类
医药卫生引用本文复制引用
LIU Lin,XIAO Feng,ZHANG Lin,HE Qian,LI Yun,ZHOU Yujuan,LIU Feng..多西他赛联合顺铂及替吉奥在局部晚期鼻咽癌中的近期临床疗效及安全性[J].肿瘤药学,2019,9(1):72-75,4.基金项目
基金项目:湖南省自然科学基金(2016JJ6088) （2016JJ6088）
中国癌症基金会北京希望马拉松专项基金(LC2016W05). （LC2016W05）
