肿瘤药学2019，Vol.9Issue(1)：143-148,6.DOI:10.3969/j.issn.2095-1264.2019.01.31
787例抗肿瘤药物不良反应特点及预后因素分析
Characteristics of Adverse Reactions of Antineoplastic Drugs in 787 Cases and the Prognosis Analysis
WANG Nana 1BAI Yu 1LIU Hong 1LI Xuemei 1ZHANG Yanhua1
作者信息
- 1. Department of Pharmacy, Peking University Cancer Hospital and Beijing Institute of Cancer Prevention and Control, Research on the Pathogenesis and Transformation of Malignant Tumors Key Laboratory of the Ministry of Education, Beijing, 100142, China
- 折叠
摘要
Abstract
Objective To study the characteristics and prognosis of the adverse reactions (ADRs) of antineoplastic drugs, thus pro-vides reference for clinical medication. Methods A retrospective study was performed on the 787 ADR cases of antineoplastic drugs which were included in the ADR report system of our hospital between January 2015 and December 2017. The distribution of primary diseases, characteristics of ADRs caused by different drugs and the clinical factors that were associated with ADR prognosis were analyzed. Results Of the 787 ADR cases, 365 cases were male and 422 cases were female, and the average age was (54.80±12.42) years. There were 34 cases of severe ADR. After drug withdrawal or therapy, 257 cases were cured, 484 cases improved, and 11 cases not improved. The prevalence of ADR in lung cancer and breast cancer were high, with 175 and 151 cases respectively. The common ADRs were myelosuppression and ana-phylaxis/anaphylactic shock. Cyclophosphamide trended to be associated with severe ADRs. ADRs caused by docetaxel often had high cure rate, but that by cisplatin had low cure rate. In addition, the prognosis of patients with weight ≤ 60 kg or gastric cancer was favorable, while that of patients with lung cancer was poor. Multiple logistic regression analysis suggested that the kinds of antineoplastic drugs and ADR counts were independent prognostic factors in patients with lung, breast or gastric cancer. Conclusion The characteristics and prognosis of the ADRs were different in patients with different features or resulted from different antineoplastic drugs. Clinically, the risk ADR should be evaluated when making therapeutic decisions and should be prevented after therapy.关键词
肿瘤治疗/药物不良反应/预后Key words
Cancer/ Adverse drug reaction/ Prognosis分类
医药卫生引用本文复制引用
WANG Nana,BAI Yu,LIU Hong,LI Xuemei,ZHANG Yanhua..787例抗肿瘤药物不良反应特点及预后因素分析[J].肿瘤药学,2019,9(1):143-148,6.
