肿瘤药学2019，Vol.9Issue(2)：184-188,5.DOI:10.3969/j.issn.2095-1264.2019.02.02
细胞外信号调节激酶与肿瘤的关系及其抑制剂的研究进展
Progress of the Correlation of Extracellular Signal-Regulated Kinase with Tumors and Its Inhibitors
摘要
Abstract
Extracellular signal-regulated kinase (ERK) is a significant molecule of signal transduction pathway. Its main function is to transfer extracellular signals step by step to the nucleus through phosphorylation and participate in many biological behaviors of cells. Studies have shown that ERK1/2 is abnormally activated or over-expressed in various tumor tissues and cells such as liver cancer, breast cancer, prostate cancer and cervical cancer. Its abnormal molecular activation is related to the occurrence and development of tumors. Therefore, ERK1/2 targeted inhibition has also become a research hotspot in cancer therapy in recent years. This review focuses on the rela-tionship between ERK1/2 and liver cancer, gastric cancer, cervical cancer and the related ERK1/2 inhibitors.关键词
细胞外信号调节激酶/肿瘤/抑制剂Key words
Extracellular signal-regulated kinase/Cancer/Inhibitors分类
医药卫生引用本文复制引用
LIU Fang,ZHAO Chuan,CHEN Che,LIU Jiajia..细胞外信号调节激酶与肿瘤的关系及其抑制剂的研究进展[J].肿瘤药学,2019,9(2):184-188,5.基金项目
国家自然科学基金资助项目(81460456). （81460456）
