肿瘤药学2019，Vol.9Issue(2)：204-207,218,5.DOI:10.3969/j.issn.2095-1264.2019.02.06
PTEN/β-catenin/Nanog在鼻咽癌组织干细胞中表达相关性的研究
Research on the Expression Correlation of PTEN, β-catenin and Nanog in Nasopharygeal Cancer Stem Cell
摘要
Abstract
Objective PTEN has been suggested to play a role in radiotherapy of head and neck tumors. β-catenin is involved in regu-lating cancer stem cells. Nanog is one of the cancer stem cells markers. This study aims to explore the correlation of the mentioned three proteins in nasopharyngeal carcinoma (NPC) tissue stem cells by testing the expression of PTEN, β-catenin and Nanog. Methods Immuno-histochemistry was used to detect the differential expression of PTEN, β-catenin (cyteblast) and Nanog (cyteblast) on a tumor issue microar-ray consisting of paraffin-embedded NPC samples derived from 130 patients. Results Negative immunostaining for PTEN was found in 62 of 130 tumors (48%).Thirty-eight (61%) out of the sixty-two specimens with negative PTEN staining displayed both nucleus β-catenin and Nanog immunoreactivity. Negative expression of PTEN in NPC was significantly associated with nuclear expression of β-catenin and Nanog. The nuclear expression of β-catenin was positively correlated with the Nanog. Conclusion The PTEN/β-catenin/Nanog axis is involved in the regulation of cancer stem cells in NPC.关键词
鼻咽癌/肿瘤干细胞/PTEN/β-catenin/NanogKey words
Nasopharyngeal carcinoma/Cancer stem cells/PTEN/β-catenin/Nanog分类
医药卫生引用本文复制引用
ZHU Wenting,ZHANG Gong,LI Xiaonan,DING Rui,REN Jinjin..PTEN/β-catenin/Nanog在鼻咽癌组织干细胞中表达相关性的研究[J].肿瘤药学,2019,9(2):204-207,218,5.基金项目
国家自然科学基金(NO.81402458). （NO.81402458）
