肿瘤药学2019，Vol.9Issue(2)：208-211,4.DOI:10.3969/j.issn.2095-1264.2019.02.07
增殖细胞核抗原Ki-67与早期乳腺癌前哨淋巴结转移及分子分型表达变化的相关性研究
Correlation of Ki-67 with Sentinel Metastasis and Molecular Typing Expression in Early Breast Cancer
摘要
Abstract
Objective To explore the relationship between the expression of proliferative cell nuclear antigen Ki-67 and early breast cancer with sentinel metastasis, and to analyze its correlation with the estrogen receptor (ER), progesterone receptor (PR) and HER-2 phe-notype status. Methods Fifty patients with early-stage breast cancer sentinel lymph node metastasis in our hospital were retrospectively analyzed. Compare the expression level of Ki-67 in the primary and sentinel lymph node metastases, and analyze whether the expression of Ki-67 would change the phenotype of ER, PR and HER-2. Results The expression of Ki-67 was positively correlated with tumor size (P=0.038), histological classification (P=0.020) and HER-2 expression (P=0.028). Compared with the primary lesion, Ki-67 had higher expression level in sentinel lymph node metastasis. No correlation was found between the expression of Ki-67 in the primary and sentinel lymph node metastases and the phenotypic states of ER, PR and HER-2. Conclusion High expression of Ki-67 may be a risk factor for early breast cancer metastasis to the sentinel node, but its expression changes do not affect the phenotype status of ER, PR and HER-2.关键词
早期乳腺癌/前哨淋巴结/增殖细胞核抗原/雌激素受体/孕激素受体/人表皮生长因子受体-2Key words
Breast cancer/Sentinel node/Ki-67/ER/PR/HER-2分类
医药卫生引用本文复制引用
TAN Miduo,CHEN Xiang,WANG Taoli,LIAO Ni,GUO Qiong,YI Jiansheng,HUANG Yan,JIANG Zuiming,ZHOU Wei..增殖细胞核抗原Ki-67与早期乳腺癌前哨淋巴结转移及分子分型表达变化的相关性研究[J].肿瘤药学,2019,9(2):208-211,4.基金项目
湖南卫生计生委项目(C2018345). （C2018345）
