肿瘤药学2019，Vol.9Issue(2)：246-249,4.DOI:10.3969/j.issn.2095-1264.2019.02.14
盐酸氮卓斯汀治疗变应性鼻炎合并非小细胞肺癌的疗效分析
Analysis on the Effect of Azostat Hydrochloride on Allergic Rhinitis Combined with NSCLC
摘要
Abstract
Objective To investigate the efficacy of azelastine hydrochloride in the treatment of allergic rhinitis combined with non-small cell lung cancer and its effect on respiratory function. Methods The data of 114 patients with allergic rhinitis combined with non-small cell lung cancer admitted to our hospital were analyzed retrospectively. The patients were divided into control group and observation group. The patients in control group were treated with cetirizine tablets orally and the patients in observation group were treated with azelastine hydro-chloride. The clinical efficacy, adverse reactions, inflammatory factors and pulmonary ventilation function were compared between the two groups. Results The clinical efficacy of the observation group was significantly better than that of the control group (P<0.05). After treat-ment, the patients in the observation group had significantly lower incidences of swollen sore throat, dizziness, drowsiness, gastrointestinal disorders, nasal obstruction and other adverse events than those in the control group (P<0.05). Before treatment, there was no difference in the levels of IL-6, CRP and TNF-α between the two groups (P>0.05). But after treatment, the levels of IL-6, CRP and TNF-α were significantly lower in observation group than in control group (P<0.05). There was also no significant difference in pulmonary ventilation function between the two groups before treatment (P>0.05), and the pulmonary ventilation function of the observation group was significantly better than that of the control group after treatment (P<0.05). Conclusion Azelastine hydrochloride treatment for allergic rhinitis patients with non-small cell lung cancer can significantly improve the clinical efficacy, reduce inflammatory factor levels, and enhance the respira-tory function of patients.关键词
盐酸氮卓斯汀/变应性鼻炎/非小细胞肺癌/呼吸功能Key words
Azelastine hydrochloride/Allergic rhinitis/Non-small cell lung cancer/Respiratory function分类
医药卫生引用本文复制引用
HUANG Yuanfei,YANG Wenzhen,HUANG Yibao,LIN Shuyu,HUANG Yifeng..盐酸氮卓斯汀治疗变应性鼻炎合并非小细胞肺癌的疗效分析[J].肿瘤药学,2019,9(2):246-249,4.基金项目
国家自然科学基金(31301143). （31301143）
