肿瘤药学2019，Vol.9Issue(2)：250-255,6.DOI:10.3969/j.issn.2095-1264.2019.02.15
多西紫杉醇联合奥沙利铂新辅助化疗对子宫颈癌的临床疗效观察
The Clinical Efficacy of Docetaxel and Oxaliplatin Neoadjuvant Chemotherapy for Patients with Cervical Cancer
摘要
Abstract
Objective To investigate the clinical efficacy of docetaxel and oxaliplatin neoadjuvant chemotherapy (NAC) for patients with cervical cancer (CC), as well as its effects on serum folic acid and expressions of mitochondrial fusion protein 2 (MFN2) and p16 proteins of patients. Methods A total of 156 cases of CC patients admitted to our hospital between July 2014 and June 2016 were enrolled into this study. The patients were divided into observation group (n=78) and control group (n=78) using the random number table method. Patients in observation group were treated with the neoadjuvant chemotherapy regimen of oxaliplatin and docetaxel, and those in control group had the chemotherapy regimen of cisplatinum and docetaxel. Detect the ratio of CD3+, CD4+, CD8+ and NK cells, and the levels of serum inter-leukin-2 (IL-2), interleukin-6 (IL-6) and interferon-gamma (IFN-γ) and indexes such as folic acid, MFN2 and p16 protein before and after chemotherapy. The clinical efficacy after chemotherapy and adverse effects during chemotherapy were also observed in the two groups. Results After chemotherapy, the levels of CD3+, CD4+,NK cells, IL-2, IFN-γ and folic acid, and the CD4+/ CD8+ in observation group were higher than in control group, while the levels of CD8+, IL-6, MFN2 and p16 protein in observation group were lower than in control group (P<0.05). Fifty-nine cases (75.64%) in observation group had their stages decreased, and the decrease rate was significantly higher than that of control group (61.54%) (P<0.05). The remission rate of the observation group (74.36%) was also significantly higher than that of control group (48.72%) (P<0.05). And the total effective rate of observation group (88.46%) was higher than that of control group (73.08%) (P<0.05). During the chemotherapy, the incidence of various toxic reactions in observation group was lower than that of control group, but the difference was not statistically significant between the two groups (P>0.05). Conclusion The chemotherapy of oxaliplatin plus docetaxel is more effective than the regimen of cisplatinum and docetaxel for cervical cancer patients. It could effectively relieve immune suppression, increase folic acid level and reduce the levels of MFN2 and p16 protein.关键词
多西紫杉醇/奥沙利铂/子宫颈癌/新辅助化疗/临床疗效Key words
Docetaxel/Oxaliplatin/Cervical cancer/Neoadjuvant chemotherapy/Clinical efficacy分类
医药卫生引用本文复制引用
WU Lingjiao,DENG Xiaoyang,XU Lei,DENG Jie,ZHU Xiaoying,WU Haiyan,PENG Cong..多西紫杉醇联合奥沙利铂新辅助化疗对子宫颈癌的临床疗效观察[J].肿瘤药学,2019,9(2):250-255,6.基金项目
四川省教育厅资助课题重点项目(17ZA0128). （17ZA0128）
