肿瘤药学2019，Vol.9Issue(2)：261-266,6.DOI:10.3969/j.issn.2095-1264.2019.02.17
miR-370、Bmi-1、Nrf2在肺癌中的表达及其与临床病理特征的相关性
Expression and Clinicopathological Features of miR-370, Bmi-1 and Nrf2 in Lung Cancer Patients
摘要
Abstract
Objective To analyze the expression of microribonucleic acid-370 (miR-370), B-cell-specific Moloney murine leukemia virus insertion site 1 (Bmi-1) and nuclear transcription-related factor-2 (Nrf2) in lung cancer and their correlation with the clinical and pathological characteristics of patients. Methods Cancer tissue specimens from 73 lung cancer patients in our hospital were selected in this study. And the paracancerous tissue specimens 5 cm away from the tumor edge of 38 lung cancer patients were retained in the same period. The expressions of miR-370, Bmi-1 and Nrf2 in lung cancer tissues and paracancerous tissues were compared, and the relationship between the expressions of miR-370, Bmi-1 and Nrf2 and the clinicopathological characteristics and prognosis of lung cancer was analyzed. Results The high expression rate of miR-370 in lung cancer tissues was lower than in the adjacent tissues, and the positive expression rates of Bmi-1 and Nrf2 were higher in lung cancer tissues than in the adjacent tissues (P<0.05). The high expression rate of mir-370 and the positive ex-pression rate of Bmi-1 and Nrf2 showed no statistical differences between different genders, ages, tumor sizes and cell types (P>0.05). But they showed statistically significant differences between different groups of lymph node metastasis, TNM staging and differentiation degree (P<0.05). The patients with high expression of miR-370 had higher survival rate than those with low expression of miR-370, and patients with Bmi-1 and Nrf2 positive expression had lower survival rate than those with negative expression (P<0.05). COX regression model anal-ysis showed that lymph node metastasis, TNM stage, Bmi-1 and Nrf2 were risk factors for prognosis, while miR-370 was a protective factor. Conclusion The expressions of miR-370, Bmi-1 and Nrf2 are correlated with the clinicopathological characteristics of lung cancer patients. The miR-370, Bmi-1 and Nrf2 could reflect the malignant biological behavior of tumors, so that could be used as a reference index for the prognosis evaluation of lung cancer patients.关键词
肺癌/微小核糖核酸-370/B细胞特异性莫洛氏鼠白血病病毒插入位点1/核转录相关因子-2/临床病理特征Key words
Lung cancer/Microrna-370/B-cell-specific Moloney murine leukemia virus insertion site 1/Nuclear transcription related factor -2/Clinicopathological features分类
医药卫生引用本文复制引用
ZHAO Wenping,YU Jihui,LUO Yue,SUN Yanli,CHEN Rong..miR-370、Bmi-1、Nrf2在肺癌中的表达及其与临床病理特征的相关性[J].肿瘤药学,2019,9(2):261-266,6.基金项目
重庆市卫计委面上资助项目(20142019). （20142019）
