肿瘤药学2019，Vol.9Issue(2)：275-279,5.DOI:10.3969/j.issn.2095-1264.2019.02.20
三维适形放疗联合阿帕替尼治疗晚期原发性肝细胞癌的疗效
Effects of Three-Dimensional Conformal Radiotherapy Combined with Apatinib in the Treatment of Advanced Hepatocellular Carcinoma
CHEN Shubo 1WU Fulin 1HANG Meng 1XU Wei1
作者信息
- 1. Department of Oncology, Wuxi No.2 People’s Hospital, Wuxi, Jiangsu, 214000, China
- 折叠
摘要
Abstract
Objective To investigate the effects of three-dimensional conformal radiotherapy (3D-CRT) combined with apatinib in the treatment of advanced hepatocellular carcinoma (AHCC). Methods A total of 86 patients with AHCC admitted to the Department of Oncology of Wuxi No.2 People's Hospital between March 2015 and June 2016 were selected as subjects. All of the patients were randomly divided into control group and observation group, 43 cases in each group. Patients in control group were treated with 3D-CRT, while patients in observation group were treated with apatinib on the basis of 3D-CRT. Enhanced CT was performed at three months after treatment. The clinical effects and adverse reactions of the two groups were compared. Serum levels of alpha-fetoprotein (AFP), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and total bilirubin (TBIL) were measured before and after treatment. All patients were followed up for two years, and the survival rates at 6 months, 1 year and 2 years were recorded. Results At three months after treatment, the disease control rate in the ob-servation group was higher than in the control group (67.4% vs. 48.8%, P<0.05). The serum levels of AFP, VEGF and bFGF in the two groups were decreased after treatment (P<0.05), and they were lower in the observation group than in the control group (P<0.05). After treatment, the TBIL level in the observation group was significantly higher than that before treatment (P<0.05). It was also higher in the observation group than in the control group after treatment (P<0.05). The incidence of hypertension and proteinuria in the observation group was higher than that in the control group (P<0.05). There was no significant difference in the incidence of nausea and vomiting, bone marrow suppression, elevated ami-notransferase, abnormal coagulation function and hand-foot syndrome between the two groups (P>0.05). No cardiotoxicity was observed in both groups. The 1-year and 2-year survival rates of the observation group were 55.8% and 34.9% respectively, which were higher than those of the control group (32.6% and 13.9%, respectively) (P<0.05). Conclusion Three-dimensional radiotherapy combined with apatinib is effective in the treatment of AHCC. It can significantly improve the long-term survival rate of patients. The adverse reactions are tolerable. Such anti-tumor effect may be related to its inhibiting tumor angiogenesis.关键词
三维适行放疗/阿帕替尼/原发性肝癌Key words
Three-dimensional conformal radiotherapy/Apatinib/Hepatocellular carcinoma分类
医药卫生引用本文复制引用
CHEN Shubo,WU Fulin,HANG Meng,XU Wei..三维适形放疗联合阿帕替尼治疗晚期原发性肝细胞癌的疗效[J].肿瘤药学,2019,9(2):275-279,5.
