肿瘤药学2019，Vol.9Issue(2)：284-286,299,4.DOI:10.3969/j.issn.2095-1264.2019.02.22
阿帕替尼联合DP方案二线治疗28例骨肉瘤术后肺转移患者的疗效观察
Efficacy of Apatinib Combined with DP Regimens for Osteosarcoma Patients with Lung Metastasis after Operation
WANG Yunqing 1ZHANG Shiqiang 2ZHU Ziqiang 1WANG Jianqiang1
作者信息
- 1. Department of Orthopaedics, the Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China
- 2. Department of Radiotherapy, the Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China
- 折叠
摘要
Abstract
Objective To observe the efficacy and safety of apatinib combined with docetaxel based regimens as the second-line treat-ment for postoperative osteosarcoma with lung metastasis. Methods From April 2015 to March 2018, 28 patients with lung metastasis from osteosarcoma and failure from first line chemotherapy were selected in this research. All patients received the treatment of apatinib com-bined with docetaxel and cisplatin. Patients were given apatinib at the dose of 425 mg·d-1 until the disease progressed. They were currently given 75 mg·m-2 docetaxel at d1 and 30 mg·m-2 cisplatin at d1- d4, 21 days as a cycle. Patients were followed up till the disease progressed. The efficacy was evaluated and the side effects were observed. The time of progress free survival (PFS) and the overall survival (OS) were recorded. Results All patients finished 4~6 cycles of chemotherapy. After two cycles of chemotherapy, CT scan images showed that the tu-mors disappeared in 2 cases (7.14%), shrank in 10 cases (35.71%) and remained unchanged in 5 cases (17.86%), and progressed in 11 cases (39.25%). The response rate was 42.86%, and disease control rate 60.71%, and 1-year survival rate 78.57%. Patients were followed up for 5~16 months. The median PFS was 7.68 months and the overall survival was 9.62 months. The main toxicities in this study included gas-trointestinal reaction, bone marrow depression and hypertension. No death was found correlated with treatment. Conclusions The treatment of apatinib combined with docetaxel and cisplatin is effective and safe as the second-line regimen for postoperative osteosarcoma patients with lung metastasis. It is worthy of further clinical study and application.关键词
阿帕替尼/多西他赛/骨肉瘤/肺转移/二线治疗Key words
Apatinib/Docetaxel/Osteosarcoma/Pulmonary metastasis/Second-line therapy分类
医药卫生引用本文复制引用
WANG Yunqing,ZHANG Shiqiang,ZHU Ziqiang,WANG Jianqiang..阿帕替尼联合DP方案二线治疗28例骨肉瘤术后肺转移患者的疗效观察[J].肿瘤药学,2019,9(2):284-286,299,4.
