肿瘤药学2019，Vol.9Issue(2)：312-316,324,6.DOI:10.3969/j.issn.2095-1264.2019.02.29
黄芪解毒汤联合GT化疗方案治疗转移性三阴性乳腺癌疗效及对患者Th1/Th2细胞因子平衡的影响
Curative Effects of Huangqi Jiedu Decoction Combined with GT Chemotherapy on Metastatic Triple-negative Breast Cancer and its Influence on Th1/Th2 Cytokine Balance
YANG Senyan 1GAO Zhiqing 2LIU Leling 1LAI Qi 1XIE Dan1
作者信息
- 1. Department of Galactophore, the First Affiliated Hospital of Guangzhou University of Tradi-tional Chinese Medicine, Guangzhou, Guangdong, 510405, China
- 2. Department of General Surgery, the First Affiliated Hospital of Guangzhou University of Tradi-tional Chinese Medicine, Guangzhou, Guangdong, 510405, China
- 折叠
摘要
Abstract
Objective To explore clinical effect of Huangqi Jiedu decoction combined with GT chemotherapy in the treatment of meta-static triple-negative breast cancer (mTNBC). Methods Selected 102 cases with mTNBC in our hospital from January 2017 to March 2018 as research objectives, and divided them into observation group (n=51) and control group (n=51) randomly. Both groups had gemcitabine +paclitaxel (GT chemotherapy), but observation group had oral Huangqi Jiedu decoction additionally. All received chemotherapy for 6 months. Compared clinical effects, total scores of symptoms, levels of serum tumor markers such as carcinoembryonic antigen (CEA) and carbohy-drate antigen 15-3 (CA15-3), and levels of helper T cells Th1 / Th2 cytokines like interleukin-6 (IL-2), interferon-γ (IFN-γ), IL-6 before and after treatments, as well as toxic side effects between the two groups. Results The objective response rate (ORR) was 45.1% (23/51) in the observation group, higher than that of control group [29.4% (15/51) ], but the difference was not statistically significant (P>0.05). However, the clinical benefit rate (CBR) of the observation group was significantly higher than that of the control group [78.4% (40/51) vs.58.8% (30/51), P<0.05]. Compared with before treatment, the total scores of symptoms and levels of serum CEA and CA15-3 decreased significantly in both groups after treatment (P<0.05), and even decreased greater in observation group than in control group (P<0.05). The serum levels of IL-2 and IFN-γ and the ratios of IL-2/IL-6 and IFN-γ/IL-6 were significant higher than those before treatment (P<0.05), while the IL-6 level decreased (P<0.05). Moreover, such improvement were found greater in observation group than in control group (P<0.05). Besides, the incidence of toxic and side effects was significantly lower in observation group than in control group [15.7% (8/51) vs.33.3% (17/51), P<0.05]. Conclusion Huangqi Jiedu decoction combined with GT chemotherapy helps mTNBC patients to alleviate the symptoms relevant with weakened body resistance and poison flourishing. It could control tumor progression, correct pathological shift of Th1/Th2 cytokine balance and reduce the side effects of chemotherapy. Consequently, Huangqi Jiedu decoction shows significant advantages in reducing toxicity and enhancing efficacy of chemotherapy.关键词
转移性三阴性乳腺癌/黄芪解毒汤/GT化疗方案/Th1/Th2细胞因子平衡/毒副反应Key words
Metastatic triple-negative breast cancer/Huangqi Jiedu decoction/GT chemotherapy regimen/Th1/Th2 cytokine balance/Toxic side effects分类
医药卫生引用本文复制引用
YANG Senyan,GAO Zhiqing,LIU Leling,LAI Qi,XIE Dan..黄芪解毒汤联合GT化疗方案治疗转移性三阴性乳腺癌疗效及对患者Th1/Th2细胞因子平衡的影响[J].肿瘤药学,2019,9(2):312-316,324,6.
