化工学报2019，Vol.70Issue(9)：3213-3227,15.DOI:10.11949/0438-1157.20190328
胶原酶研究进展与应用
Progress and application of collagenase research
摘要
Abstract
Collagen is widely distributed in various tissues of living organisms and is one of the basic proteins that constitute living organisms. The structure of collagen is more complicated than that of general protein and it displays a more stable property so that normal proteases have no significant effect to deal with it. There are only two typical enzymes have ability to hydrolyze collagen in situ , one is called matrix metalloproteinase (MMP) and another is bacterial collagenase. In this review the collagen and hydrolase are introduced in briefly, then the development process and the hydrolysis mechanism to collagen between matrix metalloproteinase and collagenase are presented, then the particular aspects of the different enzyme activities will be contextualized within relevant areas of application, mainly about therapeutics, food processing, environmental protection and tissue engineering. In the end the development of the present research and guide further potential research orientation of the system of collagen&collagenase is summarized.关键词
生物工程/酶/蛋白质/基质金属蛋白酶/微生物胶原酶Key words
bioengineering/enzyme/protein/matrix metalloproteinase/bacterial collagenase分类
生物科学引用本文复制引用
宋易航,王楚浩,方柏山..胶原酶研究进展与应用[J].化工学报,2019,70(9):3213-3227,15.基金项目
国家自然科学基金项目(21336009,41176111) （21336009,41176111）
