中国神经再生研究（英文版）2020，Vol.15Issue(3)：390-393,4.DOI:10.4103/1673-5374.266052
Dopamine as a growth differentiation factor in the mammalian brain
摘要
Abstract
The catecholamine, dopamine, plays an important role in the central nervous system of mammals, includ-ing executive functions, motor control, motivation, arousal, reinforcement, and reward. Dysfunctions of the dopaminergic system lead to diseases of the brains, such as Parkinson’s disease, Tourette’s syndrome, and schizophrenia. In addition to its fundamental role as a neurotransmitter, there is evidence for a role as a growth differentiation factor during development. Recent studies suggest that dopamine regulates the development of γ-aminobutyric acidergic interneurons of the cerebral cortex. Moreover, in adult brains, dopamine increases the production of new neurons in the hippocampus, suggesting the promoting effect of dopamine on proliferation and differentiation of neural stem cells and progenitor cells in the adult brains. In this mini-review, I center my attention on dopaminergic functions in the cortical interneurons during development and further discuss cell therapy against neurodegenerative diseases.关键词
γ-aminobutyric acidergic interneuron/ adult neurogenesis/ cerebral cortex/ dopamine/ GABA/medial ganglionic eminence/ migration/ striatumKey words
γ-aminobutyric acidergic interneuron/ adult neurogenesis/ cerebral cortex/ dopamine/ GABA/medial ganglionic eminence/ migration/ striatum引用本文复制引用
Koji Ohira..Dopamine as a growth differentiation factor in the mammalian brain[J].中国神经再生研究（英文版）,2020,15(3):390-393,4.基金项目
Funding: This work was supported by Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research [grant number JP17K07084] and Takeda Science Foundation. （）
