中国神经再生研究（英文版）2020，Vol.15Issue(3)：401-406,6.DOI:10.4103/1673-5374.266046
Can mouse models mimic sporadic Alzheimer’s disease?
摘要
Abstract
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common form of de-mentia worldwide. As age is the main risk factor, > 97% of all AD cases are of sporadic origin, potentiated by various risk factors associated with life style and starting at an age > 60 years. Only < 3% of AD cases are of genetic origin caused by mutations in the amyloid precursor protein or Presenilins 1 or 2, and symptoms already start at an age < 30 years. In order to study progression of AD, as well as therapeutic strategies, mouse models are state-of-the-art. So far many transgenic mouse models have been developed and used, with mutations in the APP or presenilin or combinations (3×Tg, 5×Tg). However, such transgenic mouse models more likely mimic the genetic form of AD and no information can be given how sporadic forms develop. Several risk genes, such as Apolipoprotein E4 and TREM-2 enhance the risk of sporadic AD, but also many risk factors associated with life style (e.g., diabetes, hypercholesterolemia, stress) may play a role. In this review we discuss the current situation regarding AD mouse models, and the problems to develop a sporadic mouse model of AD.关键词
Alzheimer’s disease/ beta-amyloid/ cerebral amyloid angiopathy/ cognitive impairment/ sporadic and genetic mouse models/ tau/ vascular risk factorsKey words
Alzheimer’s disease/ beta-amyloid/ cerebral amyloid angiopathy/ cognitive impairment/ sporadic and genetic mouse models/ tau/ vascular risk factors引用本文复制引用
Bettina M. Foidl,Christian Humpel..Can mouse models mimic sporadic Alzheimer’s disease?[J].中国神经再生研究（英文版）,2020,15(3):401-406,6.基金项目
Funding: This work was supported by the Austrian Science Funds (P24734-B24). （P24734-B24）
