首页|期刊导航|中国神经再生研究（英文版）|Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke
中国神经再生研究（英文版）2020，Vol.15Issue(3)：416-424,9.DOI:10.4103/1673-5374.265545
Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke
摘要
Abstract
Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and sub-acute phases of ischemic stroke, and highlight potential mechanisms underlying their therapeutic effects. It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.关键词
cell death/ herbal compound/ immune response/ ischemic stroke therapy/ neuroplasticity/neuroprotection/ oxidative damage/ traditional Chinese medicineKey words
cell death/ herbal compound/ immune response/ ischemic stroke therapy/ neuroplasticity/neuroprotection/ oxidative damage/ traditional Chinese medicine引用本文复制引用
Bei Zhang,Kathryn E. Saatman,Lei Chen..Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke[J].中国神经再生研究（英文版）,2020,15(3):416-424,9.基金项目
Funding: This work was supported by AHA Award 14SDG20480186 (to LC), Kentucky Spinal Cord & Head Injury Research Trust Grant 14-12A (to KES), Startup Funds from Shaanxi University of Chinese Medicine to Young Investigators (1410170078) (to BZ). （to LC）
