神经损伤与功能重建2019，Vol.14Issue(9)：433-436,453,5.DOI:10.16780/j.cnki.sjssgncj.2019.09.001
脑小血管病患者认知功能障碍与脑白质完整性及脑血流灌注的关系
Relationship between Cognitive Impairment and White Matter Integrity, Cerebral Blood Flow Perfusion in Patients with Cerebral Small Vessel Disease
摘要
Abstract
To investigate the relationship between mild cognitive impairment (MCI) and white matter integrity, cerebral blood flow perfusion in patients with cerebral small vessel disease (CSVD). Methods:A total of 52 CSVD patients with MCI were recruited and assigned to the MCI group, and 40 healthy volunteers were selected as the control group. Cognitive function was evaluated by the Montreal Cognitive Assessment Scale (MoCA); cerebral blood flow (CBF) was measured by Arterial Spin Labeling (ASL) of MR perfusion imaging technique; fractional anisotropy (FA) values and the apparent diffusion coefficient (ADC) were measured by diffusion tensor imaging (DTI). Results were analyzed to evaluate the relationship between severity of cognitive impairment and cerebral blood flow perfusion. Results: The total MoCA scale scores and visual space/execution, naming, attention/calculation, language, abstract thinking, and delayed memory scores in MCI group were significantly lower than those in control group (P<0.05). Compared with the control group, the MCI group showed decreased FA values and CBF in the bilateral centrum semiovale, bilateral frontal lobe, and apical frontal lobe (P<0.05) and increased ADC in the bilateral frontal lobe and apical frontal lobe (P<0.05). FA values in the right centrum semiovale, bilateral frontal lobe, and apical frontal lobe were positively correlated with CBF (P<0.05), and the ADC in the bilateral frontal lobe and apical frontal lobe were negatively correlated with CBF (P<0.05). FA values in the right centrum semiovale and bilateral frontal lobe were positively correlated with the MoCA score (P<0.05), and the ADC in the bilateral frontal lobe was negatively correlated with the MoCA score (P<0.05). CBF in the bilateral frontal lobe and apical frontal lobe was positively correlated with the MoCA score (P<0.05). Conclusion: In CSVD patients, the integrity of white matter is an important imaging marker of MCI and shows a relationship to cerebral perfusion.关键词
脑小血管病/认知功能障碍/脑白质/脑血流量/弥散张量成像Key words
cerebral small vessel disease/cognitive impairment/white matter/cerebral blood flow/diffusion tensor imaging分类
医药卫生引用本文复制引用
赵静,常文龙,宋伟丽,刘永刚,王潇,王宁,李宝新..脑小血管病患者认知功能障碍与脑白质完整性及脑血流灌注的关系[J].神经损伤与功能重建,2019,14(9):433-436,453,5.基金项目
保定市科技支撑计划项目(NO. 17ZF253) （NO. 17ZF253）
