肿瘤预防与治疗2019，Vol.32Issue(9)：788-799,12.DOI:10.3969/j.issn.1674-0904.2019.09.007
术前外周血血小板/淋巴细胞比值和血小板相关指标对晚期下咽鳞癌的预后价值*
Prognostic Value of Preoperative Platelet-to-Lymphocyte Ratio and Platelet-Related Indexes in Advanced Hypopharyngeal Squamous Cell Carcinoma
摘要
Abstract
Objective: To investigate whether preoperative platelet-to-lymphocyte ratio (PLR) and platelet (PLT)-related indexes, mean platelet volume (MPV) and platelet distribution width (PDW), can be long-term prognostic indicators of pa-tients with advanced (TNM Ⅲ/Ⅳ) hypopharyngeal squamous cell carcinoma (HPSCC). Method: Data of 176 HPSCC pa-tients in our hospital from January 2003 to December 2012 were retrospectively studied. X-tile method was used to select best cut-off point for preoperative blood indexes [PLR, PLT, mean platelet volume (MPV), platelet distribution width (PDW), mean platelet volume to platelet count ratio (MPV/P), platelet distribution width to platelet count ratio ( PDW/P)] to di-vide the patients into two groups (high and low). Pearson’s chi-squared test or Fisher exact test were used to conduct a de-scriptive analysis. Univariate and multivariate analysis were conducted to evaluate the relationship between clinicopathological factors like PLR and 5-year overall survival (OS) and 5-year disease-free survival (DFS) of patients in two groups. Result:Follow up was around 47. 81 months until 31 December 2017. According to X-tile method, the optimal cut-off points were 170. 8 for PLR, 260×109/L for PLT, 8. 2fL for MPV, 16. 5% for PDW, 0. 036 for MPV/P and 0. 064 for PDW/P in 5-year OS analysis. In 5-year DFS analysis, the optimal cut-off points were 139. 6 for PLR, 271×109/L for PLT, 11. 1fL for MPV, and the rest were the same as those in the 5-year OS analysis. Univariate and multivariate analysis showed that the in-dependent risk factors of 5-year OS were high PLR( >170. 8), high PLT( >260×109/L), low MPV(≤8. 2fL), tumor classification and postoperative metastasis; the independent risk factors of 5-year DFS were high PLR( >139. 6), high PDW ( >11. 1% ), tumor classification and TNM stage. Conclusion: The increase in PLR suggests that the prognosis of patients with HPSCC is poor, and it could be an indicator of long-term prognosis (5-year OS and 5-year DFS).关键词
下咽鳞癌/外周血血小板/淋巴细胞比值/血小板平均体积/血小板分布宽度Key words
Hypopharyngeal squamous cell carcinoma/Platelet-to-lymphocyte ratio/Mean platelet volume/Platelet dis-tribution width分类
医药卫生引用本文复制引用
刘会勤,陈琦,薛继尧,周梁,张明..术前外周血血小板/淋巴细胞比值和血小板相关指标对晚期下咽鳞癌的预后价值*[J].肿瘤预防与治疗,2019,32(9):788-799,12.基金项目
上海市科学技术委员会科研计划项目(编号:16411950101) （编号:16411950101）
上海市自然科学基金(编号:13ZR1406 200,17ZR1404700) This study was supported by grants from Research Pro-ject of Shanghai Municipal Science and Technology Commission (NO. 16411950101) and by Natural Sci-ence Foundation of Shanghai(NO. 13ZR1406200,NO. 17ZR1404700). （编号:13ZR1406 200,17ZR1404700）
