肿瘤预防与治疗2019，Vol.32Issue(9)：837-840,4.DOI:10.3969/j.issn.1674-0904.2019.09.013
绵阳北川羌族肺腺癌患者EGFR基因突变特点的研究*
Research on Characteristics of Epidermal Growth Factor Receptor Gene Mutation in Qiang Ethnic Patients with Lung Adenocarcinoma in Bei-chuan, Mianyang
摘要
Abstract
Objective: To explore the characteristics of epidermal growth factor receptor (EGFR) mutation in Qiang eth-nic patients with lung adenocarcinoma in Beichuan, Mianyang. Methods: Amplification refractory mutation system was used to analyze the EGFR mutations of 120 tissue samples of Qiang ethnic patients with lung adenocarcinomas, and the relationship between EGFR mutations and clinical characteris-tics was analyzed. Results: EGFR mutations were detected in 57 out of 120 lung adenocarcinoma patients. The mutation rate was 47. 5% . L858R mutation and exon 19 deletion mutation were predominant, accounting for 52. 6% (30 cases) and 42. 1% (24 cases), respectively. Among the 120 patients, the mutation rates in males and females were 60. 7% and 35. 9% , respectively (P=0. 016); mutation rates in smokers and non-smokers were 31. 0% and 56. 4% , respectively (P=0. 012). There was no significant difference in EGFR mutation rates among different age, tumor size, lymph node metastasis, tumor differentiation and cancer stage groups (P>0. 05). Conclusion: The mutation rate of EGFR in Qiang ethnic patients with lung adenocarcinomas in Mianyang is relatively high. L858R mutation and exon 19 deletion mutation were predominant. The mutation rate of EGFR is related to sex and smoking history, but not to age, tumor size, lymph node metastasis, degree of tumor differentiation and cancer stage.关键词
肺腺癌/EGFR/基因突变/羌族Key words
Lung adenocarcinoma/Epidermal growth factor receptor/Gene mutation/Qiang nationality分类
医药卫生引用本文复制引用
樊伶俐,田娟娟,张小波,张羽,杜小波..绵阳北川羌族肺腺癌患者EGFR基因突变特点的研究*[J].肿瘤预防与治疗,2019,32(9):837-840,4.基金项目
四川省卫生和计划生育委员会科研课题(编号:18PJ208,18PJ211) This study was supported by grants from Health and Family Planning Commission of Sichuan Province ( NO. 18PJ208, NO. 18PJ211). （编号:18PJ208,18PJ211）
