国际医药卫生导报2019，Vol.25Issue(17)：2865-2867,3.DOI:10.3760/cma.j.issn.1007-1245.2019.17.004
FGF23水平与心力衰竭患者结局相关性研究
Correlation between FGF23 level and outcome in patients with heart failure
摘要
Abstract
Objective To investigate the effect of fibroblast growth factor 23 (FGF23) on mortality and hospitalization risk in patients with heart failure. Methods The hospitalization examination results, all-cause death and re-hospitalization data of 252 patients with heart failure in our hospital form 2016 to 2017 were retrospectively analyzed. The plasma FGF23 levels in the 252 patients were measured. The association between FGF23 and the results was analyzed by Cox regression analysis. Results The plasma fibroblast growth factor 23 level was higher in the patients with high NYHA classification (P < 0.05); the proportion of HFPEF in the patients with a high fibroblast growth factor 23 level was significantly higher than that in those with a low level (P < 0.05). In addition, highFGF23 was associated with aldosterone, renin and hemoglobin levels. Multivariate Cox regression analysis showed that the overall endpoint of all-cause mortality and hospitalization for heart failure increased risk 1.15 (1.08-1.22) per logarithm (P < 0.05). Conclusion For patients with new-onset and worsening heart failure, elevated plasma FGF23 level is associated with volume overload, and the risk of hospitalization for all-cause death and heart failure increases.关键词
FGF23/心衰/全因死亡Key words
FGF23/Heart failure/All-cause death引用本文复制引用
林树无,王一沙,于凤霞,刘丹燕..FGF23水平与心力衰竭患者结局相关性研究[J].国际医药卫生导报,2019,25(17):2865-2867,3.基金项目
辽宁省自然科学基金指导计划(2017540884) Liaoning Natural Science Foundation Guidance Plan (2017540884) （2017540884）
