摘要
Abstract
Objective To investigate the effect of hydroxychloroquine combined with cyclophosphamide in the treatment of systemic lupus erythematosus (SLE), and to analyze its effect on the balance of Th1/Th2 cytokines in patients. Methods A total of 62 SLE patients admitted to our hospital from February, 2016 to January, 2018 were randomly divided into a control group (31 cases, treated with cyclophosphamide) and a study group (31 cases, treated with chloroquine and cyclophosphamide) according to the number table method. The incidence of discomfort during treatment, changes in treatment indicators after the treatment, and the effect on the balance of Th1/Th2 cytokines were compared between the two group. Results After the treatment, the serum contents of Alb and complement C3 were significantly higher and the 24 h urine protein quantitation, SLEDAI, ESR, Scr, and ALT were lower in the study group than in the control group (all P < 0.05); the IL-2 and TGF-β were significantly higher and the IFN-γ, IL-4, and IL-10 were significantly lower in the study group than in the control group (P < 0.05). The incidence of adverse reactions in the control group was 29.03％ (9/31), and that in the study group 12.90％ (4/31), with no statistical difference (χ 2=2.433, P=0.119). Conclusion Hydroxychloroquine combined with cyclophosphamide in the treatment of SLE can significantly change the treatment indicators, significantly decrease SLEDAI, 24 h urine protein quantitation, ESR, ESR, Scr, ALT, and improve Alb and C3 levels, and has fewer adverse reactions, and is safe.关键词
羟氯喹/环磷酰胺/系统性红斑狼疮/Th1/Th2细胞因子Key words
Hydroxychloroquine/Cyclophosphamide/Systemic lupus erythematosus/Th1/Th2 cytokines
