国际医药卫生导报2019，Vol.25Issue(18)：3027-3030,4.DOI:10.3760/cma.j.issn.1007-1245.2019.18.002
远隔缺血预处理对轻度认知功能障碍患者非体外循环冠脉搭桥术后认知功能的影响
Effect of remote ischemic preconditioning on cognitive function in patients with mild cognitive impairment after off-pump coronary artery bypass graft surgery
摘要
Abstract
Objective To evaluate the effect of remote ischemic preconditioning (RIPC) on cognitive function in patients with mild cognitive impairment (MCI) after off-pump coronary artery bypass grafting (OPCABG).Methods Sixty patients with OPCABG were enrolled,aged 65-80 years old,American Society of Anesthesiologists (ASA) grade Ⅱ or Ⅲ,judged as MCI by preoperative Montreal Scale (MoCA),Simple Intelligence Status Scale (MMSE),Dementia Scale (CDR),and the Daily Living Ability Scale (ADL).The patients were divided into 2 groups by random number table method:control group (group C,n=30) and RIPC group (group R,n=30).In group R,5 minutes after induction of anesthesia,a manometry cuff was used to give 3 cycles of 5 min ischemia (cuff inflation,pressure ≥200 mmHg) and 5 min reperfusion (cuff deflation to 0 mmHg) treatment;in group C,the cuffwas tied to the patients' right upper limb,but did not inflate and deflate.The cognitive function was evaluated by MoCA and MMSE at 1 day before surgery (T0),7 days (T1) and 30 days (T2) after surgery.Results Compared with T0,MMSE and MoCA scores were decreased at T1 in both two groups [(25.2±0.7) vs.(21.4±0.6),(25.5±0.8) vs.(22.3±0.7),(21.8±0.7) vs.(18.2±0.7),(22.0± 1.0) vs.(19.4±0.8),all P＜0.05].Compared with T1,MMSE and MoCA scores of both two groups were increased at T2 [(21.4±0.6) vs.(22.8±0.9),(22.3±0.7) vs.(23.6±0.8),(18.2±0.7) vs.(19.5±0.8),(19.4±0.8) vs.(20.7±0.9),all P＜0.05].MMSE and MoCA scores in group R were higher than those in C group from T1 to T2 (all P＜0.05).Conclusion RIPC can improve cognitive function within 30 days after OPCABG in MCI patients.关键词
远隔缺血预处理/非体外循环/心脏手术/认知功能/术后并发症Key words
Remote ischemic preconditioning/Off-pump/Heart surgery/Cognitive function/Postoperative complications引用本文复制引用
房芳,艾艳秋,孟宪慧..远隔缺血预处理对轻度认知功能障碍患者非体外循环冠脉搭桥术后认知功能的影响[J].国际医药卫生导报,2019,25(18):3027-3030,4.基金项目
河南省医学科技攻关计划项目(201602299) （201602299）
河南省医学科技攻关计划(联合共建项目)(2018020564) Henan Medical Science and Technology Key Research Project (201602299) （联合共建项目）
Henan Medical Science and Technology Key Research Project (Joint Co-construction Project) (2018020564) （Joint Co-construction Project）
