临床神经外科杂志2019，Vol.16Issue(5)：376-380,5.DOI:10.3969／j.issn.1672-7770.2019.05.002
缺血性脑血管病患者 CYP2 C19 基因多态性的相关性研究
Association of CYP2C19 gene polymorphisms in patients with ischemic cerebrovascular disease
摘要
Abstract
Objective To investigate whether the single nucleotide polymorphism ( SNP) of CYP2C19 gene in patients with ischemic cerebrovascular disease ( ICVD) is related to the clinical characteristics, ICVD, and therapeutic efficacy.To provide the evidence to make an individualized anti-platelet therapy for patients with cerebrovascular disease.Methods According to the inclusion criteria, 153 patients with CYP2C19 (*2,*3,*17 ) gene detection were recruited between January 01, 2015 and April 1, 2017 in the First Affiliated Hospital of Kunming Medical University. Gene and genotype frequency of CYP2C19 (*2,*3,*17 ) were analyzed.All patients were divided into mutation group and non-mutation group according to the results of gene detection.The correlation between CYP2C19 gene point mutation and clinical data including characteristics of patients, ICVD and ischemic events after anti-platelet therapy were analyzed.Results In this study, there were 153 patients, including 70(45.8%) male and 83(54.2%) female patients, and the average age was (53.2 ±11.6 ) years.In this study, the frequency of genotype mutations in CYP2C19(*2,*3,*17) was 53.6%, 9.2%, and 2.0%respectively.The CYP2C19*2 mutations were correlated with smoking, alcohol consumption, cholesterol ( TC), and low density lipoprotein cholesterol(LDL-C) (P＜0.05).CYP2C19*3 mutations were correlated with HDL-C(P＜0.05).There was no correlation between the three gene locus mutations of CYP2C19 and ICVD ( P ＞0.05).The ischemic events after anti-platelet therapy were significantly increased in patients with CYP2C19*2 locus mutation(P＜0.05).Conclusions The study draw the following conclusions through this clinical study. There is no significant correlation between the incidence of ICVD and the CYP 2C19(*2,*3 and*17) loci mutations.There is a statistically significance between CYP2C19*2 and ischemic events in patients with anti-platelet therapy.In this study, the mutation rate of CYP2C19*2 gene in 153 patients was as high as 53.6%.Therefore, patients should have genetic tests before receiving an anti-platelet therapy.It can reduce the possibility of poor prognosis for these patients.关键词
氯吡格雷/ CYP2C19/单核苷酸多态性/缺血性脑血管病Key words
clopidogrel/ CYP2C19/ single nucleotide polymorphism / ischemic cerebrovasc-ular disease分类
医药卫生引用本文复制引用
朱洪申,王进昆,王崇谦,李智高,彭靓,汤志伟..缺血性脑血管病患者 CYP2 C19 基因多态性的相关性研究[J].临床神经外科杂志,2019,16(5):376-380,5.基金项目
国家自然科学基金( 81760220 ) （ 81760220 ）
云南省科学技术基金( 2017FB111 ) （ 2017FB111 ）
云南省自然科学基金(2016NS058,2017NS057,2018NS0140,2017FE467-135) （2016NS058,2017NS057,2018NS0140,2017FE467-135）
