中风与神经疾病杂志2019，Vol.36Issue(8)：684-687,4.
血清淀粉样蛋白A与急性脑梗死关系的Meta分析
The relationship between serum amyloid protein A and acute ischemic stroke:A meta-analysis
摘要
Abstract
Objective To explore the relationship between serum amyloid protein A ( SAA) and acute ischemic stroke. Methods The Pub Med,Cochrane Library,China National Knowledge Infrastructure and EMbase were systematical-ly searched for prospective observational studies published up to April 2019,the language was limited to English or Chinese, and the search terms are "stroke","cerebral infarction" and "serum smyloid protein A". Studies reporting serum amyloid protein A (SAA) levels in patients with acute ischemic stroke were selected. Two reviewers independently screened litera-ture according to inclusion and exclusion criteria,and then extracted data. Meta-analysis was performed by Revman 5. 3 soft-ware. Results The level of SAA in acute ischemic stroke group was significantly higher than those in control group (MD=14. 86,95% CI=12. 09 ~17. 63,P<0. 00001). Three of the studies underwent National Institute of Health Stroke Scale (NIHSS) evaluation,the acute ischemic stroke group according to NIHSS were divided into light subgroup,medium sub-group and severe group,the results showed that the level of SAA in severe group was significantly higher than those in medi-um group (MD=1. 17,95% CI=0. 32~2. 03,P=0. 007),and the level of SAA in medium group was significantly higher than those in light group (MD=0. 60,95% CI=0. 12~1. 08,P=0. 02). Conclusion There is a significant increase of SAA level in patients suffered from acute ischemic stroke compared with the health,and SAA level is positively related to the scores of NIHSS in acute ischemic stroke patients.关键词
脑梗死/ 血清淀粉样蛋白A/ 美国国立卫生研究院卒中量表评分/ Meta分析Key words
Stroke/ Serum amyloid protein A (SAA)/ National Institute of Health Stroke Scale/ Meta-analysis分类
医药卫生引用本文复制引用
郑文惠,李倩,张磊,李北辰,方瑗..血清淀粉样蛋白A与急性脑梗死关系的Meta分析[J].中风与神经疾病杂志,2019,36(8):684-687,4.基金项目
湖北省自然科学基金(2014CFB984) （2014CFB984）
