中风与神经疾病杂志2019，Vol.36Issue(8)：714-716,3.
癫痫伴肌阵挛-失张力发作的临床及脑电图特征分析
Clinical and electroencephalographic features of Epilepsy with Myoclonic-Atonic seizures
摘要
Abstract
Objective In order to raise awareness of epilepsy with myoclonic-atonic seizures(EMAS),we explored its clinical and Video-EEG features. Methods A retrospective study on clinical and electroencephalographic ( EEG) fea-tures was carried out in 6 children diagnosed as EMAS. Results In 6 cases of EMAS,there were 5 males and one female. Normally developed before seizure onset,and no abnormality was found in brain MRI. The age of onset was two years and two months to six years. The diagnostic time is two months to one year and six months. All patients at least had two general-ized seizures types,including myoclonic-atonic,myoclonic,atonic,atypical absences. Within the 6 cases,4 cases had tonic-clonic seizure before or after above seizures,one patient had tonic seizures later. One patient had slow background in EEG, other cases appeared normal background. The interictal EEG of 6 cases present paroxysmal generalized spike/polyspike and waves discharges in 2~4 Hz,and regular or irregular poly-spike and waves discharges. In sleep stages the epileptiform dis-charges showed almost hypsarrhythmia,no case had typical focal seizures. All of cases anti-epileptic drug (AEDs). Two ca-ses were well controlled with regular antiepileptic drugs taken orally,four cases were ameliorated after additional pulse thera-py of methylprednisolone. Three cases had satisfactory prognosis during follow-up period,besides one case had still frequent discharges. Conclusions EMAS predisposes to school-age childhood. EMAS had diverse generalized seizure types,inclu-ding myoclonic-atonic,myoclonic,atonic,atypical absences EEG mainly showed generalized spike/polyspike and wave dis-charges. The majority of EMAS obtain a good prognosis by AEDs and additional hormone treatment. They had a relatively fa-vorable progosis.关键词
癫痫伴肌阵挛-失张力发作/ 脑电图/ 临床表现/ 预后Key words
Epilepsy with Myoclonic-Atonic seizures/ Electroencephalogram/ Epilepsy/ Prognosis分类
医药卫生引用本文复制引用
辛翠娟,郝小生,李秀杰,王江涛,梁建民..癫痫伴肌阵挛-失张力发作的临床及脑电图特征分析[J].中风与神经疾病杂志,2019,36(8):714-716,3.基金项目
国家自然科学基金( No. 31371125、 No. 81171220、 No. 81401068) （ No. 31371125、 No. 81171220、 No. 81401068）
