Angiogenesis and neuronal remodeling after ischemic stroke
摘要
Abstract
Increased microvessel density in the peri-infarct region has been reported and has been correlated with longer survival times in ischemic stroke patients and has improved outcomes in ischemic animal models. This raises the possibility that enhancement of angiogenesis is one of the strategies to facilitate functional recovery after ischemic stroke. Blood vessels and neuronal cells communicate with each other using vari-ous mediators and contribute to the pathophysiology of cerebral ischemia as a unit. In this mini-review, we discuss how angiogenesis might couple with axonal outgrowth/neurogenesis and work for functional re-covery after cerebral ischemia. Angiogenesis occurs within 4 to 7 days after cerebral ischemia in the border of the ischemic core and periphery. Post-ischemic angiogenesis may contribute to neuronal remodeling in at least two ways and is thought to contribute to functional recovery. First, new blood vessels that are formed after ischemia are thought to have a role in the guidance of sprouting axons by vascular endothelial growth factor and laminin/β1-integrin signaling. Second, blood vessels are thought to enhance neurogen-esis in three stages: 1) Blood vessels enhance proliferation of neural stem/progenitor cells by expression of several extracellular signals, 2) microvessels support the migration of neural stem/progenitor cells toward the peri-infarct region by supplying oxygen, nutrients, and soluble factors as well as serving as a scaffold for migration, and 3) oxygenation induced by angiogenesis in the ischemic core is thought to facilitate the differentiation of migrated neural stem/progenitor cells into mature neurons. Thus, the regions of angio-genesis and surrounding tissue may be coupled, representing novel treatment targets.关键词
angiogenesis/ axonal outgrowth/ cerebral ischemia/ coupling/ functional recovery/ guidance/neurogenesis/ strokeKey words
angiogenesis/ axonal outgrowth/ cerebral ischemia/ coupling/ functional recovery/ guidance/neurogenesis/ stroke引用本文复制引用
Masahiro Hatakeyama,Itaru Ninomiya,Masato Kanazawa..Angiogenesis and neuronal remodeling after ischemic stroke[J].中国神经再生研究（英文版）,2020,(1):16-19,4.基金项目
This work was supported by a Grant-in-Aid for Scientific Research (Research Project No. 15K19478 and 18K07493, both to MK), Japan Science and Technology Agency (JST), the Translational Research program （Research Project No. 15K19478 and 18K07493, both to MK）
Strategic Promotion for practical application of Innovative medical Technology (TR-SPRINT) supported by Japan Agency for Medical Research and Development (AMED) under Grant No. JP19lm0203023, a grant from Takeda Science Foundation, the Bayer Scholarship for Cardiovascular Research, Japan Cardiovascular Research Foundation, Astellas Foun-dation for Research on Metabolic Disorders, and Young Investigator Okamoto Award, and Medical Research Encouragement Prize of the Japan Medical Association (to MK). This work was also supported by a grant from Tsubaki Memorial Foundation (to MH and IN). （TR-SPRINT）
