中国神经再生研究（英文版）Issue(1)：20-24,5.DOI:10.4103/1673-5374.264443
δ-Opioid receptor as a potential therapeutic target for ischemic stroke
摘要
Abstract
Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a spe-cific area of brain either by arterial blockage or by narrowing of blood vessels. Despite having advancement in the use of thrombolytic and clot removal medicine, significant numbers of stroke patients are still left out without option for treatment. In this review, we summarize recent research work on the activation of δ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal injury. Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed.关键词
agonist/ AKT/ amyloid precursor protein/ BDNF/ ischemic stroke/ neuroprotection/ δ-opioid receptor/p38 MAPK/ PI3K/ TrkBKey words
agonist/ AKT/ amyloid precursor protein/ BDNF/ ischemic stroke/ neuroprotection/ δ-opioid receptor/p38 MAPK/ PI3K/ TrkB引用本文复制引用
Kalpana Subedi,Hongmin Wang..δ-Opioid receptor as a potential therapeutic target for ischemic stroke[J].中国神经再生研究（英文版）,2020,(1):20-24,5.基金项目
This work was supported by the National Institute of Neurological Disorders and Stroke under research grant NS088084 (to HW). （to HW）
