首页|期刊导航|中国神经再生研究（英文版）|Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
中国神经再生研究（英文版）Issue(1)：25-29,5.DOI:10.4103/1673-5374.264444
Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging
摘要
Abstract
Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease, Parkinson’s disease, stroke and persistent pain. Activated microglia are the main cellular source of interleukin-1β in the brain. Cathep-sin B is associated with the production and secretion of interleukin-1β through pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the phagolysosomes. The leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degrada-tion of mitochondrial transcription factor A, which can stabilize mitochondrial DNA. Therefore, microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain aging. Orally active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new phar-maceutical interventions against inflammatory brain diseases and brain aging.关键词
Key Words: brain aging/ caspase-1/ cathepsin B/ inflammatory brain diseases/ interleukin-1β/ microglia/mitochondrial transcription factor A/ neuroinflammation/ nuclear factor-κB/ oxidative stressKey words
Key Words: brain aging/ caspase-1/ cathepsin B/ inflammatory brain diseases/ interleukin-1β/ microglia/mitochondrial transcription factor A/ neuroinflammation/ nuclear factor-κB/ oxidative stress引用本文复制引用
Hiroshi Nakanishi..Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging[J].中国神经再生研究（英文版）,2020,(1):25-29,5.基金项目
This project was founded by JSPS KAKENHI, No. 24390416, JP15H05015, 15K15684 and JP16H01304 (all to HN). （all to HN）
