中国神经再生研究（英文版）Issue(1)：41-46,6.DOI:10.4103/1673-5374.264445
Selective serotonin reuptake inhibitors and Alzheimer’s disease
Bernadette Mdawar 1Elias Ghossoub 2Rita Khoury2
作者信息
- 1. Department of Psychiatry, American University of Beirut Medical Center, Beirut, Lebanon
- 2. Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School of Medicine, St. Louis, MO, USA
- 折叠
摘要
Abstract
Given the failure to develop disease-modifying therapies for Alzheimer’s disease (AD), strategies aiming at preventing or delaying the onset of the disease are being prioritized. While the debate regarding whether depression is an etiological risk factor or a prodrome of AD rages on, a key determining factor may be the timing of depression onset in older adults. There is increasing evidence that untreated early-onset depres-sion is a risk factor and that late-onset depression may be a catalyst of cognitive decline. Data from animal studies have shown a beneficial impact of selective serotonin reuptake inhibitors on pathophysiological biomarkers of AD including amyloid burden, tau deposits and neurogenesis. In humans, studies focus-ing on subjects with a prior history of depression also showed a delay in the onset of AD in those treated with most selective serotonin reuptake inhibitors. Paroxetine, which has strong anticholinergic properties, was associated with increased mortality and mixed effects on amyloid and tau deposits in mice, as well as increased odds of developing AD in humans. Although most of the data regarding selective serotonin re-uptake inhibitors is promising, findings should be interpreted cautiously because of notable methodological heterogeneity between studies. There is thus a need to conduct large scale randomized controlled trials with long follow up periods to clarify the dose-effect relationship of specific serotonergic antidepressants on AD prevention.关键词
Alzheimer’s disease/ amyloidogenesis/ animal models/ antidepressant/ depression/ onset delay/prevention/ selective serotonin reuptake inhibitor/ SSRIKey words
Alzheimer’s disease/ amyloidogenesis/ animal models/ antidepressant/ depression/ onset delay/prevention/ selective serotonin reuptake inhibitor/ SSRI引用本文复制引用
Bernadette Mdawar,Elias Ghossoub,Rita Khoury..Selective serotonin reuptake inhibitors and Alzheimer’s disease[J].中国神经再生研究（英文版）,2020,(1):41-46,6.
