中国卒中杂志2019，Vol.14Issue(7)：660-664,5.DOI:10.3969/j.issn.1673-5765.2019.07.006
急性幕上脑出血患者不同时期痫性发作与预后的关系研究
Impact of Post-hemorrhage Seizures on 1-year Outcome in Patients with Spontaneous Supratentorial Intracerebral Hemorrhage
摘要
Abstract
Objective To investigate the clinical features of epileptic seizures in patients with spontaneous supratentorial intracerebral hemorrhage (SICH), and the relation of early and delayed-onset seizures during hospitalization to the 1-year outcome. Methods Patients with acute spontaneous SICH and without epilepsy history from the China National Stroke Registry (CNSR) data from September 2007 to August 2008 were included. According to the onset time of epileptic seizure, the subjects were divided into the no-seizure group, the seizures at hemorrhage onset (SAO) group and seizures during hospitalization (SDH) group. Baseline data and the 1-year follow-up results were collected. The relation of early and delayed-onset seizure after hemorrhage to the 1-year mortality were analyzed. Results Of all the enrolled patients, 2271 patients having no seizures, 61 patients in SAO and 50 patients in SDH group. Compared to no-seizure group (21.1%), SAO (55.7%) and SDH (44%) groups had lower GCS (3-8), and the hemorrhagic foci in both the seizure groups mostly lied in the lobes and deep white matter, the difference had statistical significance (P<0.0001). While hemorrhage in the no-seizure group mostly lied in basal ganglia and deep thalamus. 1-year mortality was lowest in no-seizure group, and highest in SDH group (P<0.0001). Logistic regression analysis showed that SDH was an independent risk factor for 1-year mortality (OR 2.145, 95% CI 1.084-4.245, P=0.029). Conclusions Epileptic seizures after hemorrhage during hospitalization was an independent risk factor for 1-year mortality in patients with acute spontaneous SICH.关键词
脑出血/痫性发作/死亡率Key words
Intracerebral hemorrhage/Seizure/Mortality引用本文复制引用
刘茅茅,王丹丹,李子孝,赵性泉..急性幕上脑出血患者不同时期痫性发作与预后的关系研究[J].中国卒中杂志,2019,14(7):660-664,5.基金项目
脑出血损伤机制与干预评价研究(2018YFC1312200) 北京市医院管理局"登峰"人才培养计划(DFL20150501) 神经系统重大疾病创新药物临床评价技术平台建设(2017ZX09304018) （2018YFC1312200）
