中国卒中杂志2019，Vol.14Issue(7)：733-739,7.DOI:10.3969/j.issn.1673-5765.2019.07.016
颗粒蛋白前体在神经系统疾病中的研究进展
Progress of Role of Progranulin in Nervous System Diseases
摘要
Abstract
Progranulin (PGRN) is a multifunctional secretory glycoprotein. The abnormality in PGRN expression and related genes are closely related to nervous system inflammatory lesions, degenerative diseases, neurodegenerative diseases, brain cell lysosome homeostasis and blood-brain barrier integrity, and PGRN is involved in various pathological processes in such diseases. This article reviewed the biological effects of PGRN and progress in the role of PGRN in some neurological diseases, to provide ideas and theoretical basis for research and treatment in some neurological diseases.关键词
颗粒蛋白前体/神经系统疾病/脑梗死/血脑屏障/炎症Key words
Progranulin/Neurological disease/Cerebral infarction/Blood-brain barrier/Inflammation引用本文复制引用
张青,张蓓,李亚军..颗粒蛋白前体在神经系统疾病中的研究进展[J].中国卒中杂志,2019,14(7):733-739,7.基金项目
陕西省教育厅面上项目(14JK1629)陕西省科学技术厅一般项目(2018SF-087) （14JK1629）
