动物营养学报2019，Vol.31Issue(10)：4421-4426,6.DOI:10.3969／j.issn.1006⁃267x.2019.10.002
组蛋白去乙酰化酶调控肠道抗菌肽表达的研究进展
Research Advance on Antimicrobial Peptide Expression Regulated by Histone Deacetylase in Intestines
摘要
Abstract
Antimicrobial peptides ( AMPs) showed functions of antibacterial activity, immunomodulation and improving intestinal mucosal barriers. Given low intestinal immunity of weaned piglets, AMPs play key roles in the intestinal epithelium against pathogens invasion. However, it is difficulty to effectively improve the AMPs expression and not to cause intestinal inflammation during nutritional regulation of intestinal immunity in weaned piglets. Histone deacetylase ( HDAC) inhibitors precisely enhanced the AMPs expression by modula?ting histone modifications in the promoter region of the AMPs genes. Therefore, HDAC were important targets for the regulation of intestinal AMPs expression. In this paper, we reviewed the biological functions of AMPs, and mechanisms of AMPs expression regulated by histone modification and HDAC. In addition, we summa?rized possible mechanisms of AMPs expression regulated by nutrients via HDAC. The aim of this paper is to provide theoretical guidance for nutritional regulation of AMPs expression and improvement of intestinal immu?nity in weaned piglets.[ Chinese Journal of Animal Nutrition, 2019, 31(10) :4421?4426]关键词
抗菌肽/组蛋白去乙酰化酶/组蛋白修饰/肠道免疫/断奶仔猪Key words
antimicrobial peptide/histone deacetylase/histone modification/intestinal immunity/weaned piglets分类
农业科技引用本文复制引用
易宏波,王丽熊,云霞,蒋宗勇..组蛋白去乙酰化酶调控肠道抗菌肽表达的研究进展[J].动物营养学报,2019,31(10):4421-4426,6.基金项目
国家重点研发计划项目(2018YFD0501101,2016YFD0500501) （2018YFD0501101,2016YFD0500501）
广东省自然科学基金项目(2018A030310191) （2018A030310191）
广州市科技计划重点项目(201607020035) （201607020035）
